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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q23.2
Chromosome location (bp)
133889113 - 133895553
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001657[ureteric bud development] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0001763[morphogenesis of a branching structure] GO:0001822[kidney development] GO:0001944[vasculature development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007530[sex determination] GO:0014707[branchiomeric skeletal muscle development] GO:0030855[epithelial cell differentiation] GO:0032502[developmental process] GO:0032835[glomerulus development] GO:0043425[bHLH transcription factor binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048286[lung alveolus development] GO:0048536[spleen development] GO:0048557[embryonic digestive tract morphogenesis] GO:0048608[reproductive structure development] GO:0048732[gland development] GO:0050681[nuclear androgen receptor binding] GO:0060008[Sertoli cell differentiation] GO:0060021[roof of mouth development] GO:0060425[lung morphogenesis] GO:0060426[lung vasculature development] GO:0060435[bronchiole development] GO:0060539[diaphragm development] GO:0060541[respiratory system development] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070888[E-box binding] GO:0072162[metanephric mesenchymal cell differentiation] GO:0072277[metanephric glomerular capillary formation] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001657[ureteric bud development] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0001763[morphogenesis of a branching structure] GO:0001822[kidney development] GO:0001944[vasculature development] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007530[sex determination] GO:0007548[sex differentiation] GO:0009887[animal organ morphogenesis] GO:0014707[branchiomeric skeletal muscle development] GO:0030855[epithelial cell differentiation] GO:0032502[developmental process] GO:0032835[glomerulus development] GO:0042826[histone deacetylase binding] GO:0043425[bHLH transcription factor binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048286[lung alveolus development] GO:0048536[spleen development] GO:0048557[embryonic digestive tract morphogenesis] GO:0048608[reproductive structure development] GO:0048732[gland development] GO:0050681[nuclear androgen receptor binding] GO:0060008[Sertoli cell differentiation] GO:0060021[roof of mouth development] GO:0060425[lung morphogenesis] GO:0060426[lung vasculature development] GO:0060435[bronchiole development] GO:0060539[diaphragm development] GO:0060541[respiratory system development] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070888[E-box binding] GO:0072162[metanephric mesenchymal cell differentiation] GO:0072277[metanephric glomerular capillary formation] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
