GENERAL INFORMATIONi
Gene namei ITGB1BP1
Synonyms ICAP-1A, ICAP-1alpha, ICAP-1B, ICAP1, ICAP1A, ICAP1B
Gene descriptioni Integrin subunit beta 1 binding protein 1
Protein classi Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 2
Cytoband p25.1
Chromosome location (bp) 9403475 - 9423528
Number of transcriptsi 12
Ensembl ENSG00000119185 (version 109)
Entrez gene 9270
HGNC HGNC:23927
UniProt O14713 (UniProt - Evidence at protein level)
neXtProt NX_O14713
GeneCards ITGB1BP1
Antibodypedia ITGB1BP1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. show less
Molecular function (UniProt)i Mitogen
Biological process (UniProt)i Angiogenesis, Biomineralization, Cell adhesion, Differentiation, Notch signaling pathway, Transcription, Transcription regulation
Gene summary (Entrez)i The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
ITGB1BP1-201
ENSP00000238091
ENST00000238091
O14713
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001726 [ruffle]
GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016604 [nuclear body]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0031214 [biomineral tissue development]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0033622 [integrin activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0034451 [centriolar satellite]
GO:0035148 [tube formation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0042995 [cell projection]
GO:0043087 [regulation of GTPase activity]
GO:0043113 [receptor clustering]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051451 [myoblast migration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051781 [positive regulation of cell division]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:0072659 [protein localization to plasma membrane]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0097746 [blood vessel diameter maintenance]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 150 aa
16.1 kDa 		No 0
ITGB1BP1-202
ENSP00000347504
ENST00000355346
O14713
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001726 [ruffle]
GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016604 [nuclear body]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0031214 [biomineral tissue development]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0033622 [integrin activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0034451 [centriolar satellite]
GO:0035148 [tube formation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0042995 [cell projection]
GO:0043087 [regulation of GTPase activity]
GO:0043113 [receptor clustering]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051451 [myoblast migration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:0072659 [protein localization to plasma membrane]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0097746 [blood vessel diameter maintenance]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 200 aa
21.8 kDa 		No 0
ITGB1BP1-203
ENSP00000352743
ENST00000359712
A8MPU2
[Direct mapping] Integrin beta 1 binding protein 1, isoform CRA_g; Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0007229 [integrin-mediated signaling pathway]
Show all
 184 aa
20.2 kDa 		No 0
ITGB1BP1-204
ENSP00000353850
ENST00000360635
O14713
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001726 [ruffle]
GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016604 [nuclear body]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0031214 [biomineral tissue development]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0033622 [integrin activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0034451 [centriolar satellite]
GO:0035148 [tube formation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0042995 [cell projection]
GO:0043087 [regulation of GTPase activity]
GO:0043113 [receptor clustering]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051451 [myoblast migration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051781 [positive regulation of cell division]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:0072659 [protein localization to plasma membrane]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0097746 [blood vessel diameter maintenance]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 200 aa
21.8 kDa 		No 0
ITGB1BP1-205
ENSP00000389704
ENST00000456913
A8MPU2
[Direct mapping] Integrin beta 1 binding protein 1, isoform CRA_g; Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0007229 [integrin-mediated signaling pathway]
Show all
 184 aa
20.2 kDa 		No 0
ITGB1BP1-206
ENSP00000417850
ENST00000460001
C9J6Y2
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
Show all
 84 aa
8.9 kDa 		No 0
ITGB1BP1-211
ENSP00000419814
ENST00000467606
C9JZ07
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
Show all
 96 aa
10.2 kDa 		No 0
ITGB1BP1-215
ENSP00000418526
ENST00000484735
C9J0J6
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
Show all
 86 aa
9.1 kDa 		No 0
ITGB1BP1-216
ENSP00000419524
ENST00000488451
O14713
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001726 [ruffle]
GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:0005092 [GDP-dissociation inhibitor activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016604 [nuclear body]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0031214 [biomineral tissue development]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0033622 [integrin activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0034451 [centriolar satellite]
GO:0035148 [tube formation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0042995 [cell projection]
GO:0043087 [regulation of GTPase activity]
GO:0043113 [receptor clustering]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051451 [myoblast migration]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051781 [positive regulation of cell division]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071944 [cell periphery]
GO:0072659 [protein localization to plasma membrane]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:0097746 [blood vessel diameter maintenance]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 150 aa
16.1 kDa 		No 0
ITGB1BP1-218
ENSP00000420770
ENST00000492079
C9JBU8
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
Show all
 136 aa
14.8 kDa 		No 0
ITGB1BP1-219
ENSP00000417940
ENST00000494563
C9J5T5
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
Show all
 114 aa
12.2 kDa 		No 0
ITGB1BP1-221
ENSP00000418947
ENST00000497105
C9IZZ8
[Direct mapping] Integrin beta-1-binding protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
Show all
 65 aa
6.9 kDa 		No 0

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