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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q34.11
Chromosome location (bp)
129110950 - 129148946
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) 1,2. Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase 3. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) 4. The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex 5. Is involved in apoptosis; the function appears to be independent from PP2A 6....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Isomerase, Rotamase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Isomerase MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000159[protein phosphatase type 2A complex] GO:0000166[nucleotide binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0007052[mitotic spindle organization] GO:0008160[protein tyrosine phosphatase activator activity] GO:0016853[isomerase activity] GO:0019211[phosphatase activator activity] GO:0019888[protein phosphatase regulator activity] GO:0032515[negative regulation of phosphoprotein phosphatase activity] GO:0032516[positive regulation of phosphoprotein phosphatase activity] GO:0034704[calcium channel complex] GO:0035307[positive regulation of protein dephosphorylation] GO:0035308[negative regulation of protein dephosphorylation] GO:0042803[protein homodimerization activity] GO:0043065[positive regulation of apoptotic process] GO:0043666[regulation of phosphoprotein phosphatase activity] GO:0051721[protein phosphatase 2A binding] GO:0070062[extracellular exosome] GO:1904949[ATPase complex]
Enzymes ENZYME proteins Isomerase SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000159[protein phosphatase type 2A complex] GO:0000166[nucleotide binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0007052[mitotic spindle organization] GO:0008160[protein tyrosine phosphatase activator activity] GO:0016853[isomerase activity] GO:0019211[phosphatase activator activity] GO:0019888[protein phosphatase regulator activity] GO:0032515[negative regulation of phosphoprotein phosphatase activity] GO:0032516[positive regulation of phosphoprotein phosphatase activity] GO:0034704[calcium channel complex] GO:0035307[positive regulation of protein dephosphorylation] GO:0035308[negative regulation of protein dephosphorylation] GO:0042803[protein homodimerization activity] GO:0043065[positive regulation of apoptotic process] GO:0043666[regulation of phosphoprotein phosphatase activity] GO:0051721[protein phosphatase 2A binding] GO:0070062[extracellular exosome] GO:1904949[ATPase complex]
Enzymes ENZYME proteins Isomerase MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159[protein phosphatase type 2A complex] GO:0000166[nucleotide binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0007052[mitotic spindle organization] GO:0008160[protein tyrosine phosphatase activator activity] GO:0016853[isomerase activity] GO:0019211[phosphatase activator activity] GO:0019888[protein phosphatase regulator activity] GO:0032515[negative regulation of phosphoprotein phosphatase activity] GO:0032516[positive regulation of phosphoprotein phosphatase activity] GO:0034704[calcium channel complex] GO:0035307[positive regulation of protein dephosphorylation] GO:0035308[negative regulation of protein dephosphorylation] GO:0042803[protein homodimerization activity] GO:0043065[positive regulation of apoptotic process] GO:0043666[regulation of phosphoprotein phosphatase activity] GO:0051721[protein phosphatase 2A binding] GO:0070062[extracellular exosome] GO:1904949[ATPase complex]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
