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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q33.1
Chromosome location (bp)
116687305 - 116701300
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy 1,2. Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1 3. Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages 4. Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner 5. Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions 6. Ubiquitinates XIAP and targets it for proteasomal degradation 7. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation 8. May ubiquitinate BBS2 9. Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation 10. Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL 11. Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-45' to initiate autophagy 12....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Other congenital disorders of metabolism Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005863[striated muscle myosin thick filament] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008270[zinc ion binding] GO:0009411[response to UV] GO:0010508[positive regulation of autophagy] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0017022[myosin binding] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030957[Tat protein binding] GO:0031369[translation initiation factor binding] GO:0032897[negative regulation of viral transcription] GO:0034612[response to tumor necrosis factor] GO:0042802[identical protein binding] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130[ubiquitin binding] GO:0043621[protein self-association] GO:0044790[suppression of viral release by host] GO:0045087[innate immune response] GO:0045444[fat cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045732[positive regulation of protein catabolic process] GO:0045787[positive regulation of cell cycle] GO:0045862[positive regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:2000147[positive regulation of cell motility]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Other congenital disorders of metabolism Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Other congenital disorders of metabolism Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0001894[tissue homeostasis] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005863[striated muscle myosin thick filament] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007014[actin ubiquitination] GO:0008270[zinc ion binding] GO:0009411[response to UV] GO:0010508[positive regulation of autophagy] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0017022[myosin binding] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030957[Tat protein binding] GO:0031369[translation initiation factor binding] GO:0032897[negative regulation of viral transcription] GO:0034612[response to tumor necrosis factor] GO:0042802[identical protein binding] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130[ubiquitin binding] GO:0043621[protein self-association] GO:0044790[suppression of viral release by host] GO:0045087[innate immune response] GO:0045444[fat cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045732[positive regulation of protein catabolic process] GO:0045787[positive regulation of cell cycle] GO:0045862[positive regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046716[muscle cell cellular homeostasis] GO:0046872[metal ion binding] GO:0048147[negative regulation of fibroblast proliferation] GO:0050769[positive regulation of neurogenesis] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051155[positive regulation of striated muscle cell differentiation] GO:0061564[axon development] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1903265[positive regulation of tumor necrosis factor-mediated signaling pathway] GO:1903883[positive regulation of interleukin-17-mediated signaling pathway] GO:1903886[positive regulation of chemokine (C-C motif) ligand 20 production] GO:2000147[positive regulation of cell motility]
The Human Protein Atlas project is funded
