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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q31.1
Chromosome location (bp)
99821855 - 99866891
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) 1. In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP-glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface 2. Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q92570 [Direct mapping] Nuclear receptor subfamily 4 group A member 3
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007369[gastrulation] GO:0008270[zinc ion binding] GO:0009444[pyruvate oxidation] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010828[positive regulation of glucose transmembrane transport] GO:0019901[protein kinase binding] GO:0030522[intracellular receptor signaling pathway] GO:0032765[positive regulation of mast cell cytokine production] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035497[cAMP response element binding] GO:0035726[common myeloid progenitor cell proliferation] GO:0038097[positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0043303[mast cell degranulation] GO:0043401[steroid hormone mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0044320[cellular response to leptin stimulus] GO:0045333[cellular respiration] GO:0045444[fat cell differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046321[positive regulation of fatty acid oxidation] GO:0046872[metal ion binding] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048660[regulation of smooth muscle cell proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0071870[cellular response to catecholamine stimulus] GO:0097009[energy homeostasis] GO:1900625[positive regulation of monocyte aggregation] GO:1903208[negative regulation of hydrogen peroxide-induced neuron death] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754[positive regulation of vascular associated smooth muscle cell migration] GO:2000253[positive regulation of feeding behavior]
Q92570 [Direct mapping] Nuclear receptor subfamily 4 group A member 3
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007369[gastrulation] GO:0008270[zinc ion binding] GO:0009444[pyruvate oxidation] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010828[positive regulation of glucose transmembrane transport] GO:0019901[protein kinase binding] GO:0030522[intracellular receptor signaling pathway] GO:0032765[positive regulation of mast cell cytokine production] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035497[cAMP response element binding] GO:0035726[common myeloid progenitor cell proliferation] GO:0038097[positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0043303[mast cell degranulation] GO:0043401[steroid hormone mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0044320[cellular response to leptin stimulus] GO:0045333[cellular respiration] GO:0045444[fat cell differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046321[positive regulation of fatty acid oxidation] GO:0046872[metal ion binding] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048660[regulation of smooth muscle cell proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0071870[cellular response to catecholamine stimulus] GO:0097009[energy homeostasis] GO:1900625[positive regulation of monocyte aggregation] GO:1903208[negative regulation of hydrogen peroxide-induced neuron death] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754[positive regulation of vascular associated smooth muscle cell migration] GO:2000253[positive regulation of feeding behavior]
Q92570 [Direct mapping] Nuclear receptor subfamily 4 group A member 3
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A0A024R168 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 3, isoform CRA_c
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007369[gastrulation] GO:0008270[zinc ion binding] GO:0009444[pyruvate oxidation] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010828[positive regulation of glucose transmembrane transport] GO:0019901[protein kinase binding] GO:0030522[intracellular receptor signaling pathway] GO:0031100[animal organ regeneration] GO:0032765[positive regulation of mast cell cytokine production] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035497[cAMP response element binding] GO:0035726[common myeloid progenitor cell proliferation] GO:0038097[positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0043303[mast cell degranulation] GO:0043401[steroid hormone mediated signaling pathway] GO:0043434[response to peptide hormone] GO:0043565[sequence-specific DNA binding] GO:0044320[cellular response to leptin stimulus] GO:0045333[cellular respiration] GO:0045444[fat cell differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046321[positive regulation of fatty acid oxidation] GO:0046872[metal ion binding] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048660[regulation of smooth muscle cell proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0071870[cellular response to catecholamine stimulus] GO:0097009[energy homeostasis] GO:1900625[positive regulation of monocyte aggregation] GO:1903208[negative regulation of hydrogen peroxide-induced neuron death] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754[positive regulation of vascular associated smooth muscle cell migration] GO:2000253[positive regulation of feeding behavior]
Q92570 [Direct mapping] Nuclear receptor subfamily 4 group A member 3
Show all
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007369[gastrulation] GO:0008270[zinc ion binding] GO:0009444[pyruvate oxidation] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010828[positive regulation of glucose transmembrane transport] GO:0019901[protein kinase binding] GO:0030522[intracellular receptor signaling pathway] GO:0032765[positive regulation of mast cell cytokine production] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035497[cAMP response element binding] GO:0035726[common myeloid progenitor cell proliferation] GO:0038097[positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0043303[mast cell degranulation] GO:0043401[steroid hormone mediated signaling pathway] GO:0043565[sequence-specific DNA binding] GO:0044320[cellular response to leptin stimulus] GO:0045333[cellular respiration] GO:0045444[fat cell differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046321[positive regulation of fatty acid oxidation] GO:0046872[metal ion binding] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048660[regulation of smooth muscle cell proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0071870[cellular response to catecholamine stimulus] GO:0097009[energy homeostasis] GO:1900625[positive regulation of monocyte aggregation] GO:1903208[negative regulation of hydrogen peroxide-induced neuron death] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754[positive regulation of vascular associated smooth muscle cell migration] GO:2000253[positive regulation of feeding behavior]
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