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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p23.3
Chromosome location (bp)
24049701 - 24063681
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Isomerase, Rotamase
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000413[protein peptidyl-prolyl isomerization] GO:0002027[regulation of heart rate] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005102[signaling receptor binding] GO:0005219[ryanodine-sensitive calcium-release channel activity] GO:0005515[protein binding] GO:0005528[FK506 binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006458['de novo' protein folding] GO:0006939[smooth muscle contraction] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0009749[response to glucose] GO:0010033[response to organic substance] GO:0010459[negative regulation of heart rate] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016529[sarcoplasmic reticulum] GO:0016853[isomerase activity] GO:0019227[neuronal action potential propagation] GO:0019855[calcium channel inhibitor activity] GO:0022417[protein maturation by protein folding] GO:0030018[Z disc] GO:0030073[insulin secretion] GO:0030551[cyclic nucleotide binding] GO:0032515[negative regulation of phosphoprotein phosphatase activity] GO:0033017[sarcoplasmic reticulum membrane] GO:0033197[response to vitamin E] GO:0034704[calcium channel complex] GO:0035584[calcium-mediated signaling using intracellular calcium source] GO:0035773[insulin secretion involved in cellular response to glucose stimulus] GO:0042026[protein refolding] GO:0042098[T cell proliferation] GO:0042542[response to hydrogen peroxide] GO:0043231[intracellular membrane-bounded organelle] GO:0044325[transmembrane transporter binding] GO:0048680[positive regulation of axon regeneration] GO:0051209[release of sequestered calcium ion into cytosol] GO:0051280[negative regulation of release of sequestered calcium ion into cytosol] GO:0051284[positive regulation of sequestering of calcium ion] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0051775[response to redox state] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060315[negative regulation of ryanodine-sensitive calcium-release channel activity] GO:0061077[chaperone-mediated protein folding] GO:0061179[negative regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0086064[cell communication by electrical coupling involved in cardiac conduction]
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000413[protein peptidyl-prolyl isomerization] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005102[signaling receptor binding] GO:0005219[ryanodine-sensitive calcium-release channel activity] GO:0005515[protein binding] GO:0005528[FK506 binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006458['de novo' protein folding] GO:0010459[negative regulation of heart rate] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016529[sarcoplasmic reticulum] GO:0016853[isomerase activity] GO:0019855[calcium channel inhibitor activity] GO:0022417[protein maturation by protein folding] GO:0030018[Z disc] GO:0032515[negative regulation of phosphoprotein phosphatase activity] GO:0033017[sarcoplasmic reticulum membrane] GO:0034704[calcium channel complex] GO:0035584[calcium-mediated signaling using intracellular calcium source] GO:0042026[protein refolding] GO:0044325[transmembrane transporter binding] GO:0051280[negative regulation of release of sequestered calcium ion into cytosol] GO:0051284[positive regulation of sequestering of calcium ion] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0051775[response to redox state] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0060315[negative regulation of ryanodine-sensitive calcium-release channel activity] GO:0061077[chaperone-mediated protein folding] GO:0086064[cell communication by electrical coupling involved in cardiac conduction]
The Human Protein Atlas project is funded
