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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes FDA approved drug targets Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q14.11
Chromosome location (bp)
42562736 - 42608013
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy 1. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine, Developmental protein, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O14788 [Direct mapping] Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 11, membrane form Tumor necrosis factor ligand superfamily member 11, soluble form
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Q54A98 [Target identity:100%; Query identity:100%] Receptor activator of nuclear factor kappa B ligand 3; Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_b
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CD markers Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0002548[monocyte chemotaxis] GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0007154[cell communication] GO:0016020[membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0019722[calcium-mediated signaling] GO:0023052[signaling] GO:0030154[cell differentiation] GO:0030316[osteoclast differentiation] GO:0032813[tumor necrosis factor receptor superfamily binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034112[positive regulation of homotypic cell-cell adhesion] GO:0043406[positive regulation of MAP kinase activity] GO:0045672[positive regulation of osteoclast differentiation] GO:0045780[positive regulation of bone resorption] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050870[positive regulation of T cell activation] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051466[positive regulation of corticotropin-releasing hormone secretion] GO:0071812[positive regulation of fever generation by positive regulation of prostaglandin secretion] GO:0071847[TNFSF11-mediated signaling pathway] GO:0071848[positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling] GO:1902533[positive regulation of intracellular signal transduction]
The Human Protein Atlas project is funded
