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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q22
Chromosome location (bp)
93569814 - 93583487
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR 1,2,3,4,5. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination 6,7,8,9,10. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2 11,12,13. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR 14....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Signal transduction inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Growth regulation, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O14508 [Direct mapping] Suppressor of cytokine signaling 2
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A0A024RBD2 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001558[regulation of cell growth] GO:0005131[growth hormone receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008269[JAK pathway signal transduction adaptor activity] GO:0009966[regulation of signal transduction] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032355[response to estradiol] GO:0032870[cellular response to hormone stimulus] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0060396[growth hormone receptor signaling pathway]
O14508 [Direct mapping] Suppressor of cytokine signaling 2
Show all
A0A024RBD2 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558[regulation of cell growth] GO:0005131[growth hormone receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008269[JAK pathway signal transduction adaptor activity] GO:0009966[regulation of signal transduction] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032355[response to estradiol] GO:0032870[cellular response to hormone stimulus] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0060396[growth hormone receptor signaling pathway]
O14508 [Direct mapping] Suppressor of cytokine signaling 2
Show all
A0A024RBD2 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558[regulation of cell growth] GO:0005131[growth hormone receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008269[JAK pathway signal transduction adaptor activity] GO:0009966[regulation of signal transduction] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032355[response to estradiol] GO:0032870[cellular response to hormone stimulus] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0060396[growth hormone receptor signaling pathway]
O14508 [Direct mapping] Suppressor of cytokine signaling 2
Show all
A0A024RBD2 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558[regulation of cell growth] GO:0005131[growth hormone receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008269[JAK pathway signal transduction adaptor activity] GO:0009966[regulation of signal transduction] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032355[response to estradiol] GO:0032870[cellular response to hormone stimulus] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0060396[growth hormone receptor signaling pathway]
O14508 [Direct mapping] Suppressor of cytokine signaling 2
Show all
A0A024RBD2 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558[regulation of cell growth] GO:0005131[growth hormone receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007595[lactation] GO:0008269[JAK pathway signal transduction adaptor activity] GO:0009966[regulation of signal transduction] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032355[response to estradiol] GO:0032870[cellular response to hormone stimulus] GO:0035556[intracellular signal transduction] GO:0040014[regulation of multicellular organism growth] GO:0040015[negative regulation of multicellular organism growth] GO:0043066[negative regulation of apoptotic process] GO:0045666[positive regulation of neuron differentiation] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0060396[growth hormone receptor signaling pathway] GO:0060749[mammary gland alveolus development]
O14508 [Direct mapping] Suppressor of cytokine signaling 2
Show all
A0A024RBD2 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558[regulation of cell growth] GO:0005131[growth hormone receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0008269[JAK pathway signal transduction adaptor activity] GO:0009966[regulation of signal transduction] GO:0009968[negative regulation of signal transduction] GO:0016567[protein ubiquitination] GO:0032355[response to estradiol] GO:0032870[cellular response to hormone stimulus] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046935[1-phosphatidylinositol-3-kinase regulator activity] GO:0060396[growth hormone receptor signaling pathway]
The Human Protein Atlas project is funded
