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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q26.32
Chromosome location (bp)
179148114 - 179240093
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides 1,2,3. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) 4,5. PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others 6,7. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis, Lipid metabolism, Phagocytosis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases Atypical kinases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Congenital malformations Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001889[liver development] GO:0001932[regulation of protein phosphorylation] GO:0001944[vasculature development] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005942[phosphatidylinositol 3-kinase complex] GO:0005943[phosphatidylinositol 3-kinase complex, class IA] GO:0005944[phosphatidylinositol 3-kinase complex, class IB] GO:0006006[glucose metabolic process] GO:0006629[lipid metabolic process] GO:0006909[phagocytosis] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0008286[insulin receptor signaling pathway] GO:0010468[regulation of gene expression] GO:0010592[positive regulation of lamellipodium assembly] GO:0010629[negative regulation of gene expression] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014704[intercalated disc] GO:0014823[response to activity] GO:0014870[response to muscle inactivity] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016303[1-phosphatidylinositol-3-kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0030027[lamellipodium] GO:0030036[actin cytoskeleton organization] GO:0030168[platelet activation] GO:0030295[protein kinase activator activity] GO:0030835[negative regulation of actin filament depolymerization] GO:0031295[T cell costimulation] GO:0032008[positive regulation of TOR signaling] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035004[phosphatidylinositol 3-kinase activity] GO:0035005[1-phosphatidylinositol-4-phosphate 3-kinase activity] GO:0035994[response to muscle stretch] GO:0036092[phosphatidylinositol-3-phosphate biosynthetic process] GO:0038028[insulin receptor signaling pathway via phosphatidylinositol 3-kinase] GO:0038084[vascular endothelial growth factor signaling pathway] GO:0040014[regulation of multicellular organism growth] GO:0043201[response to leucine] GO:0043276[anoikis] GO:0043457[regulation of cellular respiration] GO:0043491[protein kinase B signaling] GO:0043524[negative regulation of neuron apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0043542[endothelial cell migration] GO:0043560[insulin receptor substrate binding] GO:0044029[hypomethylation of CpG island] GO:0046854[phosphatidylinositol phosphate biosynthetic process] GO:0046934[phosphatidylinositol-4,5-bisphosphate 3-kinase activity] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048471[perinuclear region of cytoplasm] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050852[T cell receptor signaling pathway] GO:0051897[positive regulation of protein kinase B signaling] GO:0052742[phosphatidylinositol kinase activity] GO:0052812[phosphatidylinositol-3,4-bisphosphate 5-kinase activity] GO:0055119[relaxation of cardiac muscle] GO:0060048[cardiac muscle contraction] GO:0060612[adipose tissue development] GO:0071333[cellular response to glucose stimulus] GO:0071464[cellular response to hydrostatic pressure] GO:0071548[response to dexamethasone] GO:0086003[cardiac muscle cell contraction] GO:0097009[energy homeostasis] GO:0106310[protein serine kinase activity] GO:0110053[regulation of actin filament organization] GO:1903544[response to butyrate] GO:2000270[negative regulation of fibroblast apoptotic process] GO:2000653[regulation of genetic imprinting] GO:2000811[negative regulation of anoikis]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Congenital malformations Congenital malformations of skin Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Metabolic proteins DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Congenital malformations Congenital malformations of skin Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the breast and female genital organs Congenital malformations Congenital malformations of skin Other congenital malformations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
