Expression of RPL5 in testis cancer - The Human Protein Atlas

TESTICULAR GERM CELL TUMOR (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPL5 is not prognostic in Testicular Germ Cell Tumor (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 2048.57

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

1575.6

Number of samples

133

Samples

Sample	Description	pTPM
TCGA-YU-A94D-01A	28 years, male, stage:Stage IIIB, alive, 2167 days	3928.8
TCGA-VF-A8A8-01A	18 years, male, white, stage:Stage IA, alive, 1131 days	3664.6
TCGA-XE-AAOJ-01A	24 years, male, white, stage:Stage IS, alive, 1550 days	3529.7
TCGA-2G-AAHL-01A	26 years, male, white, stage:Stage I, alive, 7081 days	2951.6
TCGA-S6-A8JY-01A	27 years, male, white, stage:Stage IS, alive, 278 days	2917.5
TCGA-XE-A8H5-01A	29 years, male, stage:Stage IS, alive, 1217 days	2805.4
TCGA-XE-AANR-01A	23 years, male, white, stage:Stage I, alive, 14 days	2792.4
TCGA-2G-AAH8-01A	45 years, male, white, stage:Stage IIIC, alive, 2248 days	2769.8
TCGA-VF-A8AC-01A	29 years, male, white, stage:Stage IA, alive, 1083 days	2760.1
TCGA-YU-A90W-01A	45 years, male, white, stage:Stage IA, alive, 1113 days	2753.6
TCGA-XE-AAO3-01A	33 years, male, asian, stage:Stage I, alive, 2857 days	2708.5
TCGA-2G-AAFJ-01A	23 years, male, asian, stage:'--, alive, 792 days	2644.2
TCGA-2G-AAH4-01A	34 years, male, white, stage:Stage II, alive, 6210 days	2613.0
TCGA-2G-AAGM-01A	51 years, male, white, stage:Stage IS, alive, 3891 days	2612.2
TCGA-2G-AAGK-01A	20 years, male, white, stage:Stage IS, alive, 3621 days	2605.2
TCGA-2G-AAG9-01A	25 years, male, white, stage:Stage IIIB, alive, 2234 days	2556.8
TCGA-YU-A912-01A	34 years, male, black or african american, stage:Stage IIIC, alive, 866 days	2448.4
TCGA-2G-AAKH-01A	19 years, male, white, stage:Stage II, alive, 6862 days	2445.1
TCGA-2G-AAGC-01A	28 years, male, white, stage:Stage IS, alive, 2585 days	2430.5
TCGA-2G-AAHG-01A	25 years, male, white, stage:Stage I, alive, 1819 days	2325.4
TCGA-2G-AAFO-01A	33 years, male, white, stage:Stage IIA, alive, 685 days	2312.5
TCGA-XE-A8H4-01A	23 years, male, white, stage:Stage IA, alive, 559 days	2285.4
TCGA-XE-A8H1-01A	24 years, male, white, stage:Stage IS, alive, 209 days	2242.9
TCGA-2G-AAFZ-01A	32 years, male, white, stage:Stage III, alive, 1353 days	2234.2
TCGA-2G-AAGX-01A	22 years, male, white, stage:Stage IA, alive, 5514 days	2191.1
TCGA-2G-AAFG-01A	30 years, male, white, stage:Stage IS, alive, 6183 days	2181.2
TCGA-2G-AAFI-01A	41 years, male, white, stage:Stage IB, alive, 675 days	2174.5
TCGA-VF-A8AA-01A	51 years, male, white, stage:Stage I, alive, 1146 days	2173.1
TCGA-XE-AAO6-01A	47 years, male, white, stage:Stage IA, alive, 240 days	2132.7
TCGA-2G-AAGV-01A	23 years, male, white, stage:'--, alive, 4527 days	2127.5
TCGA-XE-AAO4-01A	40 years, male, white, stage:Stage IA, alive, 367 days	2096.7
TCGA-VF-A8A9-01A	31 years, male, white, stage:Stage IA, alive, 1119 days	2091.7
TCGA-2G-AAG3-01A	53 years, male, white, stage:Stage IS, alive, 1593 days	2088.5
TCGA-2G-AAGZ-01A	27 years, male, white, stage:Stage IIIA, alive, 5233 days	2065.7
TCGA-2G-AAF4-01A	30 years, male, white, stage:Stage I, alive, 2315 days	2051.3
TCGA-S6-A8JW-01A	37 years, male, white, stage:Stage IS, alive, 698 days	2048.6
TCGA-2G-AAEW-01A	31 years, male, white, stage:Stage IS, dead, 618 days	2045.4
TCGA-2G-AAF1-01A	28 years, male, asian, stage:Stage IS, alive, 1403 days	2035.8
TCGA-SN-A84X-01A	21 years, male, white, stage:Stage IS, alive, 312 days	2024.1
TCGA-W4-A7U4-01A	23 years, male, white, stage:'--, alive, 738 days	2013.2
TCGA-YU-A90P-01A	25 years, male, white, stage:Stage IA, alive, 2069 days	2003.0
TCGA-2G-AAFY-01A	24 years, male, white, stage:Stage IIA, alive, 1099 days	1956.2
TCGA-2X-A9D6-01A	42 years, male, white, stage:Stage I, alive, 607 days	1932.6
TCGA-ZM-AA0B-01A	32 years, male, white, stage:Stage IA, alive, 838 days	1915.9
TCGA-XE-AANV-01A	52 years, male, stage:Stage IB, alive, 1701 days	1911.6
TCGA-2G-AAHA-01A	48 years, male, white, stage:Stage IB, alive, 3349 days	1898.8
TCGA-2G-AAF6-01A	28 years, male, white, stage:Stage IS, alive, 3491 days	1893.2
TCGA-SB-A6J6-01A	22 years, male, white, stage:Stage IA, alive, 413 days	1871.8
TCGA-2G-AALP-01A	43 years, male, white, stage:Stage IIIB, alive, 2645 days	1860.7
TCGA-WZ-A7V5-01A	27 years, male, white, stage:Stage I, alive, 1061 days	1818.5
TCGA-2G-AAH0-01A	30 years, male, white, stage:Stage IS, alive, 5477 days	1811.5
TCGA-ZM-AA06-01A	45 years, male, white, stage:Stage IB, alive, 1498 days	1809.7
TCGA-YU-A90Q-01A	21 years, male, stage:Stage IB, alive, 1964 days	1796.6
TCGA-WZ-A8D5-01A	38 years, male, white, stage:'--, alive, 774 days	1789.7
TCGA-2G-AAHN-01A	32 years, male, white, stage:Stage I, alive, 6445 days	1780.1
TCGA-2G-AAL5-01A	31 years, male, white, stage:Stage I, alive, 7437 days	1767.8
TCGA-2G-AAFM-01A	31 years, male, white, stage:Stage IIA, alive, 503 days	1766.9
TCGA-ZM-AA0N-01A	44 years, male, white, stage:Stage IB, alive, 634 days	1760.9
TCGA-W4-A7U2-01A	26 years, male, white, stage:'--, alive, 1263 days	1738.3
TCGA-2G-AAF8-01A	33 years, male, white, stage:Stage IA, alive, 3911 days	1734.4
TCGA-ZM-AA0F-01A	35 years, male, white, stage:Stage IA, alive, 681 days	1722.1
TCGA-ZM-AA0D-01A	34 years, male, white, stage:Stage IA, alive, 848 days	1719.2
TCGA-SO-A8JP-01A	29 years, male, white, stage:Stage I, alive, 540 days	1715.4
TCGA-4K-AA1H-01A	26 years, male, white, stage:Stage IA, alive, 518 days	1704.3
TCGA-2G-AAG7-01A	33 years, male, white, stage:Stage IS, alive, 2475 days	1704.2
TCGA-2G-AAG5-01A	36 years, male, white, stage:Stage IS, alive, 2299 days	1697.9
TCGA-YU-A90Y-01A	23 years, male, black or african american, stage:Stage IIIC, dead, 17 days	1686.1
TCGA-SN-A84W-01A	30 years, male, white, stage:Stage IS, alive, 293 days	1674.0
TCGA-XE-AAOC-01A	31 years, male, white, stage:Stage IA, alive, 270 days	1645.3
TCGA-ZM-AA0E-01A	39 years, male, white, stage:Stage IA, alive, 811 days	1621.5
TCGA-2G-AAHP-01A	31 years, male, white, stage:Stage IS, alive, 5667 days	1604.8
TCGA-2G-AAGI-01A	33 years, male, white, stage:Stage IS, alive, 3137 days	1580.4
TCGA-2G-AAGO-01A	41 years, male, white, stage:Stage IS, alive, 4026 days	1580.4
TCGA-2G-AAFN-01A	26 years, male, white, stage:Stage IIIB, alive, 773 days	1578.0
TCGA-2G-AAKG-01A	22 years, male, white, stage:Stage I, alive, 6598 days	1572.7
TCGA-WZ-A7V4-01A	28 years, male, white, stage:Stage I, alive, 894 days	1554.3
TCGA-VF-A8AE-01A	39 years, male, white, stage:Stage IA, alive, 727 days	1552.1
TCGA-2G-AAGP-01A	33 years, male, white, stage:Stage IIA, alive, 4018 days	1511.6
TCGA-YU-A90S-01A	26 years, male, white, stage:Stage IA, alive, 971 days	1465.7
TCGA-XE-AAOD-01A	39 years, male, white, stage:Stage IB, alive, 2058 days	1438.4
TCGA-ZM-AA0H-01A	50 years, male, white, stage:Stage IS, alive, 1736 days	1427.6
TCGA-2G-AAGJ-01A	28 years, male, black or african american, stage:Stage IA, alive, 2938 days	1414.5
TCGA-2X-A9D5-01A	49 years, male, white, stage:Stage I, alive, 435 days	1360.6
TCGA-2G-AAG6-01A	24 years, male, white, stage:Stage IS, alive, 2231 days	1359.8
TCGA-VF-A8AD-01A	36 years, male, white, stage:Stage IB, alive, 1006 days	1289.6
TCGA-4K-AA1I-01A	26 years, male, white, stage:Stage IA, alive, 3 days	1277.8
TCGA-XE-AANI-01A	37 years, male, white, stage:Stage IS, alive, 1041 days	1254.6
TCGA-2G-AAFH-01A	38 years, male, white, stage:Stage IIB, alive, 1375 days	1222.8
TCGA-2G-AAGY-01A	28 years, male, white, stage:Stage IS, alive, 5329 days	1187.9
TCGA-2G-AAG0-01A	23 years, male, white, stage:Stage IS, alive, 1529 days	1175.1
TCGA-XE-AANJ-01A	39 years, male, white, stage:Stage IS, alive, 2007 days	1166.7
TCGA-2G-AAH2-01A	20 years, male, white, stage:Stage IS, alive, 6060 days	1140.1
TCGA-2G-AAGG-01A	20 years, male, white, stage:Stage IIIC, alive, 2611 days	1125.3
TCGA-2G-AAGA-01A	38 years, male, white, stage:Stage IIA, alive, 2439 days	1099.3
TCGA-2G-AAGW-01A	38 years, male, white, stage:Stage IS, alive, 4899 days	1085.0
TCGA-4K-AA1G-01A	34 years, male, white, stage:Stage IS, alive, 436 days	1040.1
TCGA-XE-AAOB-01A	27 years, male, white, stage:Stage IS, dead, 513 days	890.0
TCGA-2G-AAGS-01A	39 years, male, white, stage:Stage IIIB, alive, 4816 days	889.5
TCGA-XE-AAOL-01A	38 years, male, black or african american, stage:Stage I, alive, 13 days	833.7
TCGA-SN-A84Y-01A	18 years, male, white, stage:Stage IS, alive, 524 days	814.6
TCGA-WZ-A7V3-01A	20 years, male, white, stage:Stage I, alive, 753 days	798.8
TCGA-4K-AAAL-01A	31 years, male, white, stage:Stage IS, alive, 483 days	796.2
TCGA-YU-AA4L-01A	27 years, male, black or african american, stage:Stage IIIC, alive, 1573 days	790.4
TCGA-SB-A76C-01A	38 years, male, white, stage:'--, alive, 42 days	762.6
TCGA-SN-A6IS-01A	26 years, male, white, stage:Stage IS, alive, 496 days	760.5
TCGA-S6-A8JX-01A	27 years, male, white, stage:Stage IB, alive, 552 days	752.9
TCGA-2G-AAHT-01A	32 years, male, white, stage:Stage IS, alive, 542 days	733.3
TCGA-2G-AAGE-01A	21 years, male, white, stage:Stage IS, alive, 2478 days	709.8
TCGA-2G-AAKL-01A	26 years, male, white, stage:Stage II, alive, 7023 days	700.7
TCGA-2G-AAH3-01A	20 years, male, white, stage:Stage I, alive, 1822 days	696.7
TCGA-2G-AAKM-01A	14 years, male, white, stage:Stage II, dead, 6972 days	685.6
TCGA-XY-A8S2-01A	67 years, male, white, stage:Stage I, alive, 672 days	638.2
TCGA-XY-A89B-01A	35 years, male, white, stage:Stage IA, alive, 471 days	635.4
TCGA-VF-A8AB-01A	31 years, male, black or african american, stage:Stage IA, alive, 760 days	629.8
TCGA-XY-A9T9-01A	37 years, male, white, stage:Stage IS, alive, 281 days	585.9
TCGA-2G-AAL7-01A	32 years, male, white, stage:Stage IS, alive, 3991 days	581.8
TCGA-XE-AAOF-01A	50 years, male, asian, stage:Stage IA, alive, 1268 days	574.1
TCGA-YU-AA61-01A	29 years, male, white, stage:Stage IS, alive, 864 days	562.5
TCGA-XE-A9SE-01A	35 years, male, white, stage:Stage IA, alive, 708 days	547.5
TCGA-2G-AAFL-01A	35 years, male, white, stage:Stage IB, alive, 750 days	508.6
TCGA-YU-A94I-01A	66 years, male, stage:Stage IA, alive, 536 days	508.4
TCGA-2G-AAFV-01A	31 years, male, white, stage:Stage IS, alive, 1389 days	500.6
TCGA-2G-AAEX-01A	38 years, male, white, stage:Stage IS, alive, 1259 days	479.8
TCGA-2G-AAGN-01A	41 years, male, white, stage:Stage IIIB, alive, 3656 days	465.9
TCGA-2G-AAHC-01A	33 years, male, white, stage:Stage IS, alive, 5539 days	461.3
TCGA-W4-A7U3-01A	26 years, male, white, stage:'--, alive, 149 days	424.3
TCGA-2G-AAGF-01A	28 years, male, white, stage:Stage IS, alive, 2734 days	417.9
TCGA-2G-AAGT-01A	30 years, male, white, stage:Stage IS, alive, 4406 days	402.9
TCGA-2G-AAFE-01A	37 years, male, white, stage:Stage IIA, alive, 4702 days	351.9
TCGA-2G-AAKD-01A	18 years, male, white, stage:Stage III, alive, 6340 days	339.7
TCGA-X3-A8G4-01A	33 years, male, white, stage:Stage IS, alive, 856 days	327.5
TCGA-2G-AAG8-01A	21 years, male, white, stage:Stage IB, alive, 2289 days	192.1
TCGA-ZM-AA05-01A	36 years, male, white, stage:Stage IIC, alive, 1126 days	155.6
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TESTIS CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA043717
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Carcinoma, Embryonal, NOS
Seminoma, NOS
Seminoma, NOS Carcinoma, Embryonal, NOS