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ZMIZ2
HPA
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  • ZMIZ2
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

ZMIZ2
Synonyms DKFZp761I2123, hZIMP7, KIAA1886, NET27, ZIMP7
Gene descriptioni

Full gene name according to HGNC.

Zinc finger MIZ-type containing 2
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 7
Cytoband p13
Chromosome location (bp) 44748581 - 44769881
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

6
Ensembl ENSG00000122515 (version 109)
Entrez gene 83637
HGNC HGNC:22229
UniProt Q8NF64 (UniProt - Evidence at protein level)
neXtProt NX_Q8NF64
GeneCards ZMIZ2
Antibodypedia ZMIZ2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.... show less
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Transcription, Transcription regulation
Ligand (UniProt)i

Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.

Metal-binding, Zinc
Gene summary (Entrez)i

Useful information about the gene from Entrez

ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005).[supplied by OMIM, May 2010]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
ZMIZ2-201
ENSP00000265346
ENST00000265346
Q8NF64
[Direct mapping] Zinc finger MIZ domain-containing protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008270 [zinc ion binding]
GO:0030374 [nuclear receptor coactivator activity]
GO:0043596 [nuclear replication fork]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0060255 [regulation of macromolecule metabolic process]
Show all
894 aa
94 kDa
No 0
ZMIZ2-202
ENSP00000311778
ENST00000309315
Q8NF64
[Direct mapping] Zinc finger MIZ domain-containing protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008270 [zinc ion binding]
GO:0030374 [nuclear receptor coactivator activity]
GO:0043596 [nuclear replication fork]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0060255 [regulation of macromolecule metabolic process]
Show all
920 aa
96.5 kDa
No 0
ZMIZ2-203
ENSP00000409648
ENST00000413916
Q8NF64
[Direct mapping] Zinc finger MIZ domain-containing protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008270 [zinc ion binding]
GO:0030374 [nuclear receptor coactivator activity]
GO:0043596 [nuclear replication fork]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0060255 [regulation of macromolecule metabolic process]
Show all
862 aa
91.1 kDa
No 0
ZMIZ2-205
ENSP00000396601
ENST00000433667
E7EWM3
[Direct mapping] Zinc finger MIZ domain-containing protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
GO:0060255 [regulation of macromolecule metabolic process]
Show all
888 aa
93.7 kDa
No 0
ZMIZ2-206
ENSP00000414723
ENST00000441627
Q8NF64
[Direct mapping] Zinc finger MIZ domain-containing protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008270 [zinc ion binding]
GO:0030374 [nuclear receptor coactivator activity]
GO:0043596 [nuclear replication fork]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0060255 [regulation of macromolecule metabolic process]
Show all
920 aa
96.5 kDa
No 0
ZMIZ2-207
ENSP00000415501
ENST00000457123
C9JDA5
[Direct mapping] Zinc finger MIZ domain-containing protein 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
89 aa
8.8 kDa
No 0

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