We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q13.13
Chromosome location (bp)
52022832 - 52059507
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' 1,2,3. Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain 4. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation 5. Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter 6. May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1
Show all
A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0030522[intracellular receptor signaling pathway] GO:0031965[nuclear membrane] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035767[endothelial cell chemotaxis] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0043565[sequence-specific DNA binding] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045444[fat cell differentiation] GO:0045786[negative regulation of cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0098793[presynapse] GO:1990837[sequence-specific double-stranded DNA binding]
P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0030522[intracellular receptor signaling pathway] GO:0031965[nuclear membrane] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035767[endothelial cell chemotaxis] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0043565[sequence-specific DNA binding] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045444[fat cell differentiation] GO:0045786[negative regulation of cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0098793[presynapse] GO:1990837[sequence-specific double-stranded DNA binding]
P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1
Show all
A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0030522[intracellular receptor signaling pathway] GO:0031965[nuclear membrane] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035767[endothelial cell chemotaxis] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0043565[sequence-specific DNA binding] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045444[fat cell differentiation] GO:0045786[negative regulation of cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0098793[presynapse] GO:1990837[sequence-specific double-stranded DNA binding]
P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1
Show all
A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0001975[response to amphetamine] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0014860[neurotransmitter secretion involved in regulation of skeletal muscle contraction] GO:0030522[intracellular receptor signaling pathway] GO:0031965[nuclear membrane] GO:0032496[response to lipopolysaccharide] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035767[endothelial cell chemotaxis] GO:0035914[skeletal muscle cell differentiation] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0042802[identical protein binding] GO:0043065[positive regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045444[fat cell differentiation] GO:0045786[negative regulation of cell cycle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0051602[response to electrical stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071310[cellular response to organic substance] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0098793[presynapse] GO:1990837[sequence-specific double-stranded DNA binding]
F5GXF0 [Direct mapping] Nuclear receptor subfamily 4 group A member 1
Show all
Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0030522[intracellular receptor signaling pathway] GO:0031965[nuclear membrane] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035767[endothelial cell chemotaxis] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0043565[sequence-specific DNA binding] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045444[fat cell differentiation] GO:0045786[negative regulation of cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0098793[presynapse] GO:1990837[sequence-specific double-stranded DNA binding]
P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1
Show all
Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0030522[intracellular receptor signaling pathway] GO:0031965[nuclear membrane] GO:0035259[nuclear glucocorticoid receptor binding] GO:0035767[endothelial cell chemotaxis] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0043565[sequence-specific DNA binding] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045444[fat cell differentiation] GO:0045786[negative regulation of cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0050896[response to stimulus] GO:0061469[regulation of type B pancreatic cell proliferation] GO:0071376[cellular response to corticotropin-releasing hormone stimulus] GO:0098793[presynapse] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
