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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.12
Chromosome location (bp)
47501887 - 47656877
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Acyltransferase, Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000993[RNA polymerase II complex binding] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0032870[cellular response to hormone stimulus] GO:0032991[protein-containing complex] GO:0035624[receptor transactivation] GO:0043697[cell dedifferentiation] GO:0045618[positive regulation of keratinocyte differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046966[nuclear thyroid hormone receptor binding] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0060090[molecular adaptor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070062[extracellular exosome] GO:0071392[cellular response to estradiol stimulus] GO:0097718[disordered domain specific binding] GO:1902459[positive regulation of stem cell population maintenance] GO:2000035[regulation of stem cell division]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000993[RNA polymerase II complex binding] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0032870[cellular response to hormone stimulus] GO:0032991[protein-containing complex] GO:0035624[receptor transactivation] GO:0043697[cell dedifferentiation] GO:0045618[positive regulation of keratinocyte differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046966[nuclear thyroid hormone receptor binding] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0060090[molecular adaptor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070062[extracellular exosome] GO:0071392[cellular response to estradiol stimulus] GO:0097718[disordered domain specific binding] GO:1902459[positive regulation of stem cell population maintenance] GO:2000035[regulation of stem cell division]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000993[RNA polymerase II complex binding] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0032870[cellular response to hormone stimulus] GO:0032991[protein-containing complex] GO:0035624[receptor transactivation] GO:0043697[cell dedifferentiation] GO:0045618[positive regulation of keratinocyte differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046966[nuclear thyroid hormone receptor binding] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0060090[molecular adaptor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070062[extracellular exosome] GO:0071392[cellular response to estradiol stimulus] GO:0097718[disordered domain specific binding] GO:1902459[positive regulation of stem cell population maintenance] GO:2000035[regulation of stem cell division]
The Human Protein Atlas project is funded
