We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p11.2
Chromosome location (bp)
20999596 - 21043760
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator 1,2,3. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Facilitates cell-cycle progression by stabilizing CCNB1 and antagonizing its proteasome-mediated degradation in a cell cycle-specific manner 4. Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation through deacetylase SIRT1 stabilization 5. Plays multiple roles in immunity and inflammation. Participates in antiviral response by deubiquitinating the importin KPNA2, leading to IRF3 nuclear translocation and subsequent type I interferon production 6. Acts as a central regulator of type III IFN signaling by negatively regulating STING1 activation and ubiquitination 7. Inhibits NLRP3 inflammasome activation by promoting NLRP3 degradation through ATG5-dependent autophagy (By similarity). Deubiquitinates CD274 to induce its stabilization and thereby participates in maintenance of immune tolerance to self 8. Controls necroptotic cell death by regulating RIPK3 phosphorylation and ubiquitination 9. During bacterial infection, promotes pro-inflammatory response by targeting TRAF6 and removing its 'Lys-48'-linked polyubiquitination (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent deubiquitinase. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000124[SAGA complex] GO:0003713[transcription coactivator activity] GO:0004843[cysteine-type deubiquitinase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006282[regulation of DNA repair] GO:0006325[chromatin organization] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006508[proteolysis] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007049[cell cycle] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008270[zinc ion binding] GO:0009792[embryo development ending in birth or egg hatching] GO:0010485[histone H4 acetyltransferase activity] GO:0016574[histone ubiquitination] GO:0016578[histone deubiquitination] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0019899[enzyme binding] GO:0030374[nuclear receptor coactivator activity] GO:0033276[transcription factor TFTC complex] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0043484[regulation of RNA splicing] GO:0043966[histone H3 acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0046872[metal ion binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843[cysteine-type deubiquitinase activity] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008270[zinc ion binding] GO:0016579[protein deubiquitination] GO:0046872[metal ion binding]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000124[SAGA complex] GO:0003713[transcription coactivator activity] GO:0004843[cysteine-type deubiquitinase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006282[regulation of DNA repair] GO:0006325[chromatin organization] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006508[proteolysis] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007049[cell cycle] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008270[zinc ion binding] GO:0009792[embryo development ending in birth or egg hatching] GO:0010485[histone H4 acetyltransferase activity] GO:0016574[histone ubiquitination] GO:0016578[histone deubiquitination] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0019899[enzyme binding] GO:0030374[nuclear receptor coactivator activity] GO:0033276[transcription factor TFTC complex] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0043484[regulation of RNA splicing] GO:0043966[histone H3 acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0046872[metal ion binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843[cysteine-type deubiquitinase activity] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008270[zinc ion binding] GO:0016579[protein deubiquitination] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
