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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q12
Chromosome location (bp)
39404285 - 39451272
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors 1,2,3,4,5,6,7,8,9,10,11. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells 12....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q15648 [Direct mapping] Mediator of RNA polymerase II transcription subunit 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000902[cell morphogenesis] GO:0001223[transcription coactivator binding] GO:0001525[angiogenesis] GO:0001701[in utero embryonic development] GO:0001889[liver development] GO:0001892[embryonic placenta development] GO:0002088[lens development in camera-type eye] GO:0002154[thyroid hormone mediated signaling pathway] GO:0003222[ventricular trabecula myocardium morphogenesis] GO:0003406[retinal pigment epithelium development] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006590[thyroid hormone generation] GO:0006606[protein import into nucleus] GO:0006702[androgen biosynthetic process] GO:0007420[brain development] GO:0007507[heart development] GO:0007595[lactation] GO:0008284[positive regulation of cell population proliferation] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0010839[negative regulation of keratinocyte proliferation] GO:0016020[membrane] GO:0016592[mediator complex] GO:0016922[nuclear receptor binding] GO:0030216[keratinocyte differentiation] GO:0030224[monocyte differentiation] GO:0030331[nuclear estrogen receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0031100[animal organ regeneration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0033148[positive regulation of intracellular estrogen receptor signaling pathway] GO:0033598[mammary gland epithelial cell proliferation] GO:0035050[embryonic heart tube development] GO:0035116[embryonic hindlimb morphogenesis] GO:0035162[embryonic hemopoiesis] GO:0035357[peroxisome proliferator activated receptor signaling pathway] GO:0035729[cellular response to hepatocyte growth factor stimulus] GO:0035855[megakaryocyte development] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042809[nuclear vitamin D receptor binding] GO:0042974[nuclear retinoic acid receptor binding] GO:0042975[peroxisome proliferator activated receptor binding] GO:0043010[camera-type eye development] GO:0043066[negative regulation of apoptotic process] GO:0044877[protein-containing complex binding] GO:0045023[G0 to G1 transition] GO:0045444[fat cell differentiation] GO:0045618[positive regulation of keratinocyte differentiation] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045665[negative regulation of neuron differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046966[nuclear thyroid hormone receptor binding] GO:0048821[erythrocyte development] GO:0048822[enucleate erythrocyte development] GO:0050693[LBD domain binding] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060218[hematopoietic stem cell differentiation] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0060335[positive regulation of interferon-gamma-mediated signaling pathway] GO:0060744[mammary gland branching involved in thelarche] GO:0060745[mammary gland branching involved in pregnancy] GO:0060750[epithelial cell proliferation involved in mammary gland duct elongation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070318[positive regulation of G0 to G1 transition] GO:0070562[regulation of vitamin D receptor signaling pathway] GO:0070847[core mediator complex] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071383[cellular response to steroid hormone stimulus] GO:0097067[cellular response to thyroid hormone stimulus] GO:0140297[DNA-binding transcription factor binding] GO:1990841[promoter-specific chromatin binding] GO:2000347[positive regulation of hepatocyte proliferation] GO:2001141[regulation of RNA biosynthetic process]
Q15648 [Direct mapping] Mediator of RNA polymerase II transcription subunit 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000902[cell morphogenesis] GO:0001223[transcription coactivator binding] GO:0001525[angiogenesis] GO:0002088[lens development in camera-type eye] GO:0002154[thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006702[androgen biosynthetic process] GO:0010628[positive regulation of gene expression] GO:0010839[negative regulation of keratinocyte proliferation] GO:0016020[membrane] GO:0016592[mediator complex] GO:0016922[nuclear receptor binding] GO:0030216[keratinocyte differentiation] GO:0030331[nuclear estrogen receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035855[megakaryocyte development] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042809[nuclear vitamin D receptor binding] GO:0042974[nuclear retinoic acid receptor binding] GO:0042975[peroxisome proliferator activated receptor binding] GO:0043066[negative regulation of apoptotic process] GO:0045444[fat cell differentiation] GO:0045618[positive regulation of keratinocyte differentiation] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045665[negative regulation of neuron differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046966[nuclear thyroid hormone receptor binding] GO:0048821[erythrocyte development] GO:0050693[LBD domain binding] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0070847[core mediator complex] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071383[cellular response to steroid hormone stimulus] GO:0097067[cellular response to thyroid hormone stimulus] GO:0140297[DNA-binding transcription factor binding] GO:2001141[regulation of RNA biosynthetic process]
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