GENERAL INFORMATIONi
Gene namei CITED1
Synonyms MSG1
Gene descriptioni Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome X
Cytoband q13.1
Chromosome location (bp) 72301638 - 72307187
Number of transcriptsi 11
Ensembl ENSG00000125931 (version 109)
Entrez gene 4435
HGNC HGNC:1986
UniProt Q99966 (UniProt - Evidence at protein level)
neXtProt NX_Q99966
GeneCards CITED1
Antibodypedia CITED1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. show less
Molecular function (UniProt)i Activator, Developmental protein
Biological process (UniProt)i Apoptosis, Differentiation, Transcription, Transcription regulation
Gene summary (Entrez)i This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
CITED1-201
ENSP00000246139
ENST00000246139
Q99966
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to type II interferon]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
Show all
 193 aa
19.9 kDa 		No 0
CITED1-202
ENSP00000362721
ENST00000373619
Q99966
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to type II interferon]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
Show all
 193 aa
19.9 kDa 		No 0
CITED1-203
ENSP00000414781
ENST00000417400
C9JRD8
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
 140 aa
14.1 kDa 		No 0
CITED1-204
ENSP00000391407
ENST00000427412
C9J300
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
 138 aa
14.2 kDa 		No 0
CITED1-205
ENSP00000407496
ENST00000429794
H7C2S6
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
 106 aa
11.2 kDa 		No 0
CITED1-206
ENSP00000388548
ENST00000431381
Q99966
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to type II interferon]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
Show all
 219 aa
22.6 kDa 		No 0
CITED1-207
ENSP00000403274
ENST00000445983
Q99966
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to type II interferon]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
Show all
 193 aa
19.9 kDa 		No 0
CITED1-208
ENSP00000405765
ENST00000450875
C9J7P8
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
 109 aa
11 kDa 		No 0
CITED1-209
ENSP00000401764
ENST00000453707
Q99966
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to type II interferon]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
Show all
 219 aa
22.6 kDa 		No 0
CITED1-210
ENSP00000412769
ENST00000454225
C9J1P6
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
 59 aa
6.2 kDa 		No 0
CITED1-211
ENSP00000499148
ENST00000651998
Q99966
[Direct mapping] Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007420 [brain development]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to type II interferon]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0060711 [labyrinthine layer development]
GO:0060712 [spongiotrophoblast layer development]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
Show all
 193 aa
19.9 kDa 		No 0

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