We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.21
Chromosome location (bp)
31605283 - 31606515
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P41134 [Direct mapping] DNA-binding protein inhibitor ID-1
Show all
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001525[angiogenesis] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0010621[negative regulation of transcription by transcription factor localization] GO:0030154[cell differentiation] GO:0032922[circadian regulation of gene expression] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043534[blood vessel endothelial cell migration] GO:0045892[negative regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0048511[rhythmic process] GO:0048514[blood vessel morphogenesis] GO:0120163[negative regulation of cold-induced thermogenesis] GO:0140416[transcription regulator inhibitor activity]
P41134 [Direct mapping] DNA-binding protein inhibitor ID-1
Show all
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001525[angiogenesis] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005813[centrosome] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007420[brain development] GO:0008022[protein C-terminus binding] GO:0010621[negative regulation of transcription by transcription factor localization] GO:0010628[positive regulation of gene expression] GO:0014070[response to organic cyclic compound] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0032091[negative regulation of protein binding] GO:0032233[positive regulation of actin filament bundle assembly] GO:0032922[circadian regulation of gene expression] GO:0036164[cell-abiotic substrate adhesion] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043534[blood vessel endothelial cell migration] GO:0045602[negative regulation of endothelial cell differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0048511[rhythmic process] GO:0048514[blood vessel morphogenesis] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050774[negative regulation of dendrite morphogenesis] GO:0070628[proteasome binding] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0120163[negative regulation of cold-induced thermogenesis] GO:0140416[transcription regulator inhibitor activity] GO:1901342[regulation of vasculature development] GO:1901653[cellular response to peptide] GO:1903351[cellular response to dopamine] GO:1990090[cellular response to nerve growth factor stimulus]
The Human Protein Atlas project is funded
