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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q32.33
Chromosome location (bp)
103697609 - 103715504
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA recombination, DNA repair
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q53XC8 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human); X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair complementing defective repair in Chinese hamster cells 3, isoform CRA_a; cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3; cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3; cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000400[four-way junction DNA binding] GO:0000722[telomere maintenance via recombination] GO:0000724[double-strand break repair via homologous recombination] GO:0000781[chromosome, telomeric region] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005657[replication fork] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0008821[crossover junction endodeoxyribonuclease activity] GO:0010824[regulation of centrosome duplication] GO:0033065[Rad51C-XRCC3 complex] GO:0036297[interstrand cross-link repair] GO:0045003[double-strand break repair via synthesis-dependent strand annealing] GO:0048471[perinuclear region of cytoplasm] GO:0071140[resolution of mitotic recombination intermediates] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:0090304[nucleic acid metabolic process] GO:0090656[t-circle formation] GO:0090657[telomeric loop disassembly] GO:0090737[telomere maintenance via telomere trimming] GO:0140664[ATP-dependent DNA damage sensor activity]
Q53XC8 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human); X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair complementing defective repair in Chinese hamster cells 3, isoform CRA_a; cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3; cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3; cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0000400[four-way junction DNA binding] GO:0000722[telomere maintenance via recombination] GO:0000724[double-strand break repair via homologous recombination] GO:0000781[chromosome, telomeric region] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005657[replication fork] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0008821[crossover junction endodeoxyribonuclease activity] GO:0010824[regulation of centrosome duplication] GO:0033065[Rad51C-XRCC3 complex] GO:0036297[interstrand cross-link repair] GO:0045003[double-strand break repair via synthesis-dependent strand annealing] GO:0048471[perinuclear region of cytoplasm] GO:0071140[resolution of mitotic recombination intermediates] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:0090304[nucleic acid metabolic process] GO:0090656[t-circle formation] GO:0090657[telomeric loop disassembly] GO:0090737[telomere maintenance via telomere trimming] GO:0140664[ATP-dependent DNA damage sensor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Protein evidence (Ezkurdia et al 2014)
Q53XC8 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human); X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair complementing defective repair in Chinese hamster cells 3, isoform CRA_a; cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3; cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3; cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000400[four-way junction DNA binding] GO:0000722[telomere maintenance via recombination] GO:0000724[double-strand break repair via homologous recombination] GO:0000781[chromosome, telomeric region] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005657[replication fork] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0008821[crossover junction endodeoxyribonuclease activity] GO:0010824[regulation of centrosome duplication] GO:0033065[Rad51C-XRCC3 complex] GO:0036297[interstrand cross-link repair] GO:0045003[double-strand break repair via synthesis-dependent strand annealing] GO:0048471[perinuclear region of cytoplasm] GO:0071140[resolution of mitotic recombination intermediates] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:0090304[nucleic acid metabolic process] GO:0090656[t-circle formation] GO:0090657[telomeric loop disassembly] GO:0090737[telomere maintenance via telomere trimming] GO:0140664[ATP-dependent DNA damage sensor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Protein evidence (Ezkurdia et al 2014)
Q53XC8 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human); X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair complementing defective repair in Chinese hamster cells 3, isoform CRA_a; cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3; cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3; cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0000400[four-way junction DNA binding] GO:0000722[telomere maintenance via recombination] GO:0000724[double-strand break repair via homologous recombination] GO:0000781[chromosome, telomeric region] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005657[replication fork] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006310[DNA recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0008821[crossover junction endodeoxyribonuclease activity] GO:0010033[response to organic substance] GO:0010824[regulation of centrosome duplication] GO:0033065[Rad51C-XRCC3 complex] GO:0036297[interstrand cross-link repair] GO:0045003[double-strand break repair via synthesis-dependent strand annealing] GO:0048471[perinuclear region of cytoplasm] GO:0071140[resolution of mitotic recombination intermediates] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:0090304[nucleic acid metabolic process] GO:0090656[t-circle formation] GO:0090657[telomeric loop disassembly] GO:0090737[telomere maintenance via telomere trimming] GO:0140664[ATP-dependent DNA damage sensor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Skin cancers Cancers of the breast and female genital organs Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
