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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q34
Chromosome location (bp)
113177536 - 113208715
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores 1. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability 2. Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
mRNA transport, Protein transport, Translocation, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q5JVF3 [Direct mapping] PCI domain-containing protein 2
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A0A024RE04 [Target identity:100%; Query identity:100%] PCI domain-containing protein 2
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000973[post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005737[cytoplasm] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0015031[protein transport] GO:0016973[poly(A)+ mRNA export from nucleus] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0043488[regulation of mRNA stability] GO:0044615[nuclear pore nuclear basket] GO:0045893[positive regulation of DNA-templated transcription] GO:0048536[spleen development] GO:0051028[mRNA transport] GO:0060633[negative regulation of transcription initiation by RNA polymerase II] GO:0070390[transcription export complex 2] GO:0070828[heterochromatin organization] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1905457[negative regulation of lymphoid progenitor cell differentiation] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q5JVF3 [Direct mapping] PCI domain-containing protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000973[post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005737[cytoplasm] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0015031[protein transport] GO:0016973[poly(A)+ mRNA export from nucleus] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0043488[regulation of mRNA stability] GO:0044615[nuclear pore nuclear basket] GO:0045579[positive regulation of B cell differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0048536[spleen development] GO:0051028[mRNA transport] GO:0060633[negative regulation of transcription initiation by RNA polymerase II] GO:0070390[transcription export complex 2] GO:0070828[heterochromatin organization] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1905457[negative regulation of lymphoid progenitor cell differentiation] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q5JVF3 [Direct mapping] PCI domain-containing protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000973[post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005737[cytoplasm] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0015031[protein transport] GO:0016973[poly(A)+ mRNA export from nucleus] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0043488[regulation of mRNA stability] GO:0044615[nuclear pore nuclear basket] GO:0045893[positive regulation of DNA-templated transcription] GO:0048536[spleen development] GO:0051028[mRNA transport] GO:0060633[negative regulation of transcription initiation by RNA polymerase II] GO:0070390[transcription export complex 2] GO:0070828[heterochromatin organization] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1905457[negative regulation of lymphoid progenitor cell differentiation] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q5JVF3 [Direct mapping] PCI domain-containing protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000973[post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005737[cytoplasm] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0015031[protein transport] GO:0016973[poly(A)+ mRNA export from nucleus] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0043488[regulation of mRNA stability] GO:0044615[nuclear pore nuclear basket] GO:0045893[positive regulation of DNA-templated transcription] GO:0048536[spleen development] GO:0051028[mRNA transport] GO:0060633[negative regulation of transcription initiation by RNA polymerase II] GO:0070390[transcription export complex 2] GO:0070828[heterochromatin organization] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1905457[negative regulation of lymphoid progenitor cell differentiation] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q5JVF3 [Direct mapping] PCI domain-containing protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000973[post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005737[cytoplasm] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0015031[protein transport] GO:0016973[poly(A)+ mRNA export from nucleus] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0043488[regulation of mRNA stability] GO:0044615[nuclear pore nuclear basket] GO:0045893[positive regulation of DNA-templated transcription] GO:0048536[spleen development] GO:0051028[mRNA transport] GO:0060633[negative regulation of transcription initiation by RNA polymerase II] GO:0070390[transcription export complex 2] GO:0070828[heterochromatin organization] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1905457[negative regulation of lymphoid progenitor cell differentiation] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q5JVF3 [Direct mapping] PCI domain-containing protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000973[post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005737[cytoplasm] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0015031[protein transport] GO:0016973[poly(A)+ mRNA export from nucleus] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0043488[regulation of mRNA stability] GO:0044615[nuclear pore nuclear basket] GO:0045893[positive regulation of DNA-templated transcription] GO:0048536[spleen development] GO:0051028[mRNA transport] GO:0060633[negative regulation of transcription initiation by RNA polymerase II] GO:0070390[transcription export complex 2] GO:0070828[heterochromatin organization] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1905457[negative regulation of lymphoid progenitor cell differentiation] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
Q5JVF3 [Direct mapping] PCI domain-containing protein 2
Show all
A0A024RE04 [Target identity:100%; Query identity:100%] PCI domain-containing protein 2
Show all
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000973[post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery] GO:0003690[double-stranded DNA binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005643[nuclear pore] GO:0005737[cytoplasm] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0015031[protein transport] GO:0016973[poly(A)+ mRNA export from nucleus] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0043488[regulation of mRNA stability] GO:0044615[nuclear pore nuclear basket] GO:0045893[positive regulation of DNA-templated transcription] GO:0048536[spleen development] GO:0051028[mRNA transport] GO:0060633[negative regulation of transcription initiation by RNA polymerase II] GO:0070390[transcription export complex 2] GO:0070828[heterochromatin organization] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1905457[negative regulation of lymphoid progenitor cell differentiation] GO:2000117[negative regulation of cysteine-type endopeptidase activity]
The Human Protein Atlas project is funded
