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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.2
Chromosome location (bp)
42287547 - 42311943
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P42229 [Direct mapping] Signal transducer and activator of transcription 5A
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A0A384N5W4 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007595[lactation] GO:0019221[cytokine-mediated signaling pathway] GO:0019530[taurine metabolic process] GO:0038026[reelin-mediated signaling pathway] GO:0040014[regulation of multicellular organism growth] GO:0042127[regulation of cell population proliferation] GO:0043434[response to peptide hormone] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140297[DNA-binding transcription factor binding]
P42229 [Direct mapping] Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007595[lactation] GO:0019221[cytokine-mediated signaling pathway] GO:0019530[taurine metabolic process] GO:0038026[reelin-mediated signaling pathway] GO:0040014[regulation of multicellular organism growth] GO:0042127[regulation of cell population proliferation] GO:0043434[response to peptide hormone] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140297[DNA-binding transcription factor binding]
P42229 [Direct mapping] Signal transducer and activator of transcription 5A
Show all
A0A384N5W4 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007595[lactation] GO:0019221[cytokine-mediated signaling pathway] GO:0019530[taurine metabolic process] GO:0038026[reelin-mediated signaling pathway] GO:0040014[regulation of multicellular organism growth] GO:0042127[regulation of cell population proliferation] GO:0043434[response to peptide hormone] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140297[DNA-binding transcription factor binding]
P42229 [Direct mapping] Signal transducer and activator of transcription 5A
Show all
A0A384N5W4 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007595[lactation] GO:0019221[cytokine-mediated signaling pathway] GO:0019530[taurine metabolic process] GO:0038026[reelin-mediated signaling pathway] GO:0040014[regulation of multicellular organism growth] GO:0042127[regulation of cell population proliferation] GO:0043434[response to peptide hormone] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140297[DNA-binding transcription factor binding]
P42229 [Direct mapping] Signal transducer and activator of transcription 5A
Show all
A0A384N5W4 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001938[positive regulation of endothelial cell proliferation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007595[lactation] GO:0019221[cytokine-mediated signaling pathway] GO:0019530[taurine metabolic process] GO:0038026[reelin-mediated signaling pathway] GO:0040014[regulation of multicellular organism growth] GO:0042127[regulation of cell population proliferation] GO:0043434[response to peptide hormone] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140297[DNA-binding transcription factor binding]
The Human Protein Atlas project is funded
