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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.2
Chromosome location (bp)
9835257 - 9849689
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs 1,2,3. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes 4,5,6. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK 7. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation 8. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner 9. Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN 10. May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) 11,12. Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells 13....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Isomerase, Rotamase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle
Gene summary (Entrez)i
Useful information about the gene from Entrez
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000413[protein peptidyl-prolyl isomerization] GO:0001666[response to hypoxia] GO:0001932[regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0003774[cytoskeletal motor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0007088[regulation of mitotic nuclear division] GO:0008013[beta-catenin binding] GO:0010468[regulation of gene expression] GO:0016607[nuclear speck] GO:0016853[isomerase activity] GO:0016859[cis-trans isomerase activity] GO:0030182[neuron differentiation] GO:0030496[midbody] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031647[regulation of protein stability] GO:0032091[negative regulation of protein binding] GO:0032092[positive regulation of protein binding] GO:0032465[regulation of cytokinesis] GO:0032794[GTPase activating protein binding] GO:0035307[positive regulation of protein dephosphorylation] GO:0036064[ciliary basal body] GO:0042177[negative regulation of protein catabolic process] GO:0043547[positive regulation of GTPase activity] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048156[tau protein binding] GO:0050808[synapse organization] GO:0050815[phosphoserine residue binding] GO:0050816[phosphothreonine residue binding] GO:0050821[protein stabilization] GO:0051171[regulation of nitrogen compound metabolic process] GO:0051219[phosphoprotein binding] GO:0051443[positive regulation of ubiquitin-protein transferase activity] GO:0060255[regulation of macromolecule metabolic process] GO:0060393[regulation of pathway-restricted SMAD protein phosphorylation] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0080090[regulation of primary metabolic process] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0098978[glutamatergic synapse] GO:0099524[postsynaptic cytosol] GO:1900180[regulation of protein localization to nucleus] GO:1902430[negative regulation of amyloid-beta formation] GO:2000146[negative regulation of cell motility]
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000413[protein peptidyl-prolyl isomerization] GO:0001666[response to hypoxia] GO:0001932[regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0003774[cytoskeletal motor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0007088[regulation of mitotic nuclear division] GO:0008013[beta-catenin binding] GO:0010468[regulation of gene expression] GO:0016607[nuclear speck] GO:0016853[isomerase activity] GO:0016859[cis-trans isomerase activity] GO:0030182[neuron differentiation] GO:0030496[midbody] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031647[regulation of protein stability] GO:0032091[negative regulation of protein binding] GO:0032092[positive regulation of protein binding] GO:0032465[regulation of cytokinesis] GO:0032794[GTPase activating protein binding] GO:0035307[positive regulation of protein dephosphorylation] GO:0036064[ciliary basal body] GO:0042177[negative regulation of protein catabolic process] GO:0043547[positive regulation of GTPase activity] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048156[tau protein binding] GO:0050808[synapse organization] GO:0050815[phosphoserine residue binding] GO:0050816[phosphothreonine residue binding] GO:0050821[protein stabilization] GO:0051171[regulation of nitrogen compound metabolic process] GO:0051219[phosphoprotein binding] GO:0051443[positive regulation of ubiquitin-protein transferase activity] GO:0060255[regulation of macromolecule metabolic process] GO:0060393[regulation of pathway-restricted SMAD protein phosphorylation] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0080090[regulation of primary metabolic process] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0098978[glutamatergic synapse] GO:0099524[postsynaptic cytosol] GO:1900180[regulation of protein localization to nucleus] GO:1902430[negative regulation of amyloid-beta formation] GO:2000146[negative regulation of cell motility]
The Human Protein Atlas project is funded
