GENERAL INFORMATIONi
Gene namei ATF4
Synonyms CREB-2, TAXREB67, TXREB
Gene descriptioni Activating transcription factor 4
Protein classi Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 22
Cytoband q13.1
Chromosome location (bp) 39519695 - 39522683
Number of transcriptsi 11
Ensembl ENSG00000128272 (version 109)
Entrez gene 468
HGNC HGNC:786
UniProt P18848 (UniProt - Evidence at protein level)
neXtProt NX_P18848
GeneCards ATF4
Antibodypedia ATF4 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) 1, 2, 3, 4. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress 5. During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery 6, 7. Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress 8. Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress 9. However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation 10. Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress 11. May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress 12. In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix 13. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding 14. show less
Molecular function (UniProt)i Activator, DNA-binding, Repressor
Biological process (UniProt)i Biological rhythms, Transcription, Transcription regulation
Gene summary (Entrez)i This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
ATF4-201
ENSP00000336790
ENST00000337304
P18848
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0008140 [cAMP response element binding protein binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030282 [bone mineralization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034599 [cellular response to oxidative stress]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035162 [embryonic hemopoiesis]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045943 [positive regulation of transcription by RNA polymerase I]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070982 [L-asparagine metabolic process]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140467 [integrated stress response signaling]
GO:0140468 [HRI-mediated signaling]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903351 [cellular response to dopamine]
GO:1990037 [Lewy body core]
GO:1990253 [cellular response to leucine starvation]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-202
ENSP00000379912
ENST00000396680
P18848
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0008140 [cAMP response element binding protein binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030282 [bone mineralization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034599 [cellular response to oxidative stress]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035162 [embryonic hemopoiesis]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045943 [positive regulation of transcription by RNA polymerase I]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070982 [L-asparagine metabolic process]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140467 [integrated stress response signaling]
GO:0140468 [HRI-mediated signaling]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903351 [cellular response to dopamine]
GO:1990037 [Lewy body core]
GO:1990253 [cellular response to leucine starvation]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-203
ENSP00000384587
ENST00000404241
P18848
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0008140 [cAMP response element binding protein binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030282 [bone mineralization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034599 [cellular response to oxidative stress]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035162 [embryonic hemopoiesis]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045943 [positive regulation of transcription by RNA polymerase I]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070982 [L-asparagine metabolic process]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140467 [integrated stress response signaling]
GO:0140468 [HRI-mediated signaling]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903351 [cellular response to dopamine]
GO:1990037 [Lewy body core]
GO:1990253 [cellular response to leucine starvation]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-204
ENSP00000501783
ENST00000674568
P18848
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
A0A6Q8PFH6
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0008140 [cAMP response element binding protein binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030282 [bone mineralization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034599 [cellular response to oxidative stress]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035162 [embryonic hemopoiesis]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045943 [positive regulation of transcription by RNA polymerase I]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070982 [L-asparagine metabolic process]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140467 [integrated stress response signaling]
GO:0140468 [HRI-mediated signaling]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903351 [cellular response to dopamine]
GO:1990037 [Lewy body core]
GO:1990253 [cellular response to leucine starvation]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-205
ENSP00000502610
ENST00000674835
P18848
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
A0A6Q8PHB3
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0008140 [cAMP response element binding protein binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030282 [bone mineralization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034599 [cellular response to oxidative stress]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035162 [embryonic hemopoiesis]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045943 [positive regulation of transcription by RNA polymerase I]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070982 [L-asparagine metabolic process]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140467 [integrated stress response signaling]
GO:0140468 [HRI-mediated signaling]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903351 [cellular response to dopamine]
GO:1990037 [Lewy body core]
GO:1990253 [cellular response to leucine starvation]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-206
ENSP00000501863
ENST00000674920
P18848
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007623 [circadian rhythm]
GO:0008022 [protein C-terminus binding]
GO:0008140 [cAMP response element binding protein binding]
GO:0009636 [response to toxic substance]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030182 [neuron differentiation]
GO:0030282 [bone mineralization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0032590 [dendrite membrane]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034599 [cellular response to oxidative stress]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035162 [embryonic hemopoiesis]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045943 [positive regulation of transcription by RNA polymerase I]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070169 [positive regulation of biomineral tissue development]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070982 [L-asparagine metabolic process]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0090650 [cellular response to oxygen-glucose deprivation]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140296 [general transcription initiation factor binding]
GO:0140297 [DNA-binding transcription factor binding]
GO:0140467 [integrated stress response signaling]
GO:0140468 [HRI-mediated signaling]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903351 [cellular response to dopamine]
GO:1905461 [positive regulation of vascular associated smooth muscle cell apoptotic process]
GO:1990037 [Lewy body core]
GO:1990253 [cellular response to leucine starvation]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990737 [response to manganese-induced endoplasmic reticulum stress]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
GO:2000120 [positive regulation of sodium-dependent phosphate transport]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-207
ENSP00000502056
ENST00000675582
A0A6Q8PG17
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
 322 aa
35.5 kDa 		No 0
ATF4-208
ENSP00000502400
ENST00000676346
P18848
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
A0A6Q8PGY1
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0008140 [cAMP response element binding protein binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030282 [bone mineralization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034599 [cellular response to oxidative stress]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035162 [embryonic hemopoiesis]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045943 [positive regulation of transcription by RNA polymerase I]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070982 [L-asparagine metabolic process]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140467 [integrated stress response signaling]
GO:0140468 [HRI-mediated signaling]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903351 [cellular response to dopamine]
GO:1990037 [Lewy body core]
GO:1990253 [cellular response to leucine starvation]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-209
ENSP00000505360
ENST00000679776
P18848
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006366 [transcription by RNA polymerase II]
GO:0008140 [cAMP response element binding protein binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030282 [bone mineralization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034599 [cellular response to oxidative stress]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035162 [embryonic hemopoiesis]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045943 [positive regulation of transcription by RNA polymerase I]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048511 [rhythmic process]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070982 [L-asparagine metabolic process]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140467 [integrated stress response signaling]
GO:0140468 [HRI-mediated signaling]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903351 [cellular response to dopamine]
GO:1990037 [Lewy body core]
GO:1990253 [cellular response to leucine starvation]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:1990841 [promoter-specific chromatin binding]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-210
ENSP00000506657
ENST00000680446
B4DJD4
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
 267 aa
29.6 kDa 		No 0
ATF4-211
ENSP00000506141
ENST00000680748
A0A7P0Z4J5
[Direct mapping] Cyclic AMP-dependent transcription factor ATF-4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
 97 aa
10.4 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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