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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q11.2
Chromosome location (bp)
24823637 - 24978723
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May be involved in tissue-specific alternative RNA processing events....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ribonucleoprotein, RNA-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P63162 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
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X5DP00 [Target identity:100%; Query identity:100%] HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level
P63162 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
Show all
X5DP00 [Target identity:100%; Query identity:100%] HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level
P63162 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
Show all
X5DP00 [Target identity:100%; Query identity:100%] HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level
P63162 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
Show all
X5DP00 [Target identity:100%; Query identity:100%] HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level
P63162 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level
P63162 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
Show all
X5DP00 [Target identity:100%; Query identity:100%] HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level
J3QLE5 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities
J3KRY3 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities
P63162 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
Show all
X5DP00 [Target identity:100%; Query identity:100%] HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level
P63162 [Direct mapping] Small nuclear ribonucleoprotein-associated protein N
Show all
X5DP00 [Target identity:100%; Query identity:100%] HCG15924, isoform CRA_a; Small nuclear ribonucleoprotein polypeptide N isoform A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level
The Human Protein Atlas project is funded
