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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
ChaC glutathione specific gamma-glutamylcyclotransferase 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q15.1
Chromosome location (bp)
40952962 - 40956512
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides 1. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade 2. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos 3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Lyase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Neurogenesis, Notch signaling pathway, Unfolded protein response
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Lyases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003839[gamma-glutamylcyclotransferase activity] GO:0005112[Notch binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005802[trans-Golgi network] GO:0005829[cytosol] GO:0006750[glutathione biosynthetic process] GO:0006751[glutathione catabolic process] GO:0006915[apoptotic process] GO:0006986[response to unfolded protein] GO:0007219[Notch signaling pathway] GO:0007399[nervous system development] GO:0010955[negative regulation of protein processing] GO:0016829[lyase activity] GO:0022008[neurogenesis] GO:0045746[negative regulation of Notch signaling pathway] GO:0061928[glutathione specific gamma-glutamylcyclotransferase activity] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
Enzymes ENZYME proteins Lyases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003839[gamma-glutamylcyclotransferase activity] GO:0005112[Notch binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005802[trans-Golgi network] GO:0005829[cytosol] GO:0006750[glutathione biosynthetic process] GO:0006751[glutathione catabolic process] GO:0006915[apoptotic process] GO:0006986[response to unfolded protein] GO:0007219[Notch signaling pathway] GO:0007399[nervous system development] GO:0010955[negative regulation of protein processing] GO:0016829[lyase activity] GO:0022008[neurogenesis] GO:0045746[negative regulation of Notch signaling pathway] GO:0061928[glutathione specific gamma-glutamylcyclotransferase activity] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
The Human Protein Atlas project is funded
