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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.4
Chromosome location (bp)
2883213 - 2885775
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protein kinase inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of endocrine organs Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
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GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005634[nucleus] GO:0007346[regulation of mitotic cell cycle] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051726[regulation of cell cycle] GO:0060255[regulation of macromolecule metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Cancers of endocrine organs Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0033673[negative regulation of kinase activity] GO:0042326[negative regulation of phosphorylation] GO:0044877[protein-containing complex binding] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045930[negative regulation of mitotic cell cycle] GO:0050680[negative regulation of epithelial cell proliferation] GO:0051726[regulation of cell cycle] GO:0060255[regulation of macromolecule metabolic process] GO:0140678[molecular function inhibitor activity] GO:1904030[negative regulation of cyclin-dependent protein kinase activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Cancers of endocrine organs Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0033673[negative regulation of kinase activity] GO:0042326[negative regulation of phosphorylation] GO:0044877[protein-containing complex binding] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045930[negative regulation of mitotic cell cycle] GO:0050680[negative regulation of epithelial cell proliferation] GO:0051726[regulation of cell cycle] GO:0060255[regulation of macromolecule metabolic process] GO:0140678[molecular function inhibitor activity] GO:1904030[negative regulation of cyclin-dependent protein kinase activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Cancers of endocrine organs Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001501[skeletal system development] GO:0001822[kidney development] GO:0001890[placenta development] GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0007049[cell cycle] GO:0007096[regulation of exit from mitosis] GO:0007346[regulation of mitotic cell cycle] GO:0007568[aging] GO:0030099[myeloid cell differentiation] GO:0030325[adrenal gland development] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0033673[negative regulation of kinase activity] GO:0035264[multicellular organism growth] GO:0042326[negative regulation of phosphorylation] GO:0042551[neuron maturation] GO:0043010[camera-type eye development] GO:0044877[protein-containing complex binding] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045930[negative regulation of mitotic cell cycle] GO:0050680[negative regulation of epithelial cell proliferation] GO:0051726[regulation of cell cycle] GO:0055123[digestive system development] GO:0060065[uterus development] GO:0060255[regulation of macromolecule metabolic process] GO:0060669[embryonic placenta morphogenesis] GO:0071514[genomic imprinting] GO:0140678[molecular function inhibitor activity] GO:1902746[regulation of lens fiber cell differentiation] GO:1904030[negative regulation of cyclin-dependent protein kinase activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of endocrine organs Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005634[nucleus] GO:0007346[regulation of mitotic cell cycle] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051726[regulation of cell cycle] GO:0060255[regulation of macromolecule metabolic process]
The Human Protein Atlas project is funded
