GENERAL INFORMATIONi
Gene namei CHMP2A
Synonyms BC-2, CHMP2, VPS2, VPS2A
Gene descriptioni Charged multivesicular body protein 2A
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 19
Cytoband q13.43
Chromosome location (bp) 58551452 - 58555105
Number of transcriptsi 6
Ensembl ENSG00000130724 (version 109)
Entrez gene 27243
HGNC HGNC:30216
UniProt O43633 (UniProt - Evidence at protein level)
neXtProt NX_O43633
GeneCards CHMP2A
Antibodypedia CHMP2A antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis 1. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase 2. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 3. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. show less
Biological process (UniProt)i Host-virus interaction, Protein transport, Transport
Gene summary (Entrez)i CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006).[supplied by OMIM, Mar 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
CHMP2A-201
ENSP00000310440
ENST00000312547
O43633
[Direct mapping] Charged multivesicular body protein 2a
Show all
A0A024R4S0
[Target identity:100%; Query identity:100%] Chromatin modifying protein 2A, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000421 [autophagosome membrane]
GO:0000776 [kinetochore]
GO:0000785 [chromatin]
GO:0000815 [ESCRT III complex]
GO:0001778 [plasma membrane repair]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005771 [multivesicular body]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006914 [autophagy]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0008333 [endosome to lysosome transport]
GO:0010324 [membrane invagination]
GO:0010458 [exit from mitosis]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019076 [viral release from host cell]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0030496 [midbody]
GO:0031210 [phosphatidylcholine binding]
GO:0031468 [nuclear membrane reassembly]
GO:0031902 [late endosome membrane]
GO:0032509 [endosome transport via multivesicular body sorting pathway]
GO:0032585 [multivesicular body membrane]
GO:0036258 [multivesicular body assembly]
GO:0039702 [viral budding via host ESCRT complex]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045184 [establishment of protein localization]
GO:0045324 [late endosome to vacuole transport]
GO:0046761 [viral budding from plasma membrane]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051469 [vesicle fusion with vacuole]
GO:0060548 [negative regulation of cell death]
GO:0061763 [multivesicular body-lysosome fusion]
GO:0061952 [midbody abscission]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:0090148 [membrane fission]
GO:0097352 [autophagosome maturation]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902774 [late endosome to lysosome transport]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903723 [negative regulation of centriole elongation]
GO:1904903 [ESCRT III complex disassembly]
GO:1904930 [amphisome membrane]
Show all
 222 aa
25.1 kDa 		No 0
CHMP2A-202
ENSP00000471961
ENST00000596708
O43633
[Direct mapping] Charged multivesicular body protein 2a
Show all
M0R1L7
[Direct mapping] Charged multivesicular body protein 2a
A0A024R4S0
[Target identity:100%; Query identity:100%] Chromatin modifying protein 2A, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000421 [autophagosome membrane]
GO:0000776 [kinetochore]
GO:0000785 [chromatin]
GO:0000815 [ESCRT III complex]
GO:0001778 [plasma membrane repair]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005771 [multivesicular body]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006914 [autophagy]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0008333 [endosome to lysosome transport]
GO:0010324 [membrane invagination]
GO:0010458 [exit from mitosis]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019076 [viral release from host cell]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0030496 [midbody]
GO:0031210 [phosphatidylcholine binding]
GO:0031468 [nuclear membrane reassembly]
GO:0031902 [late endosome membrane]
GO:0032509 [endosome transport via multivesicular body sorting pathway]
GO:0032585 [multivesicular body membrane]
GO:0036258 [multivesicular body assembly]
GO:0039702 [viral budding via host ESCRT complex]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045184 [establishment of protein localization]
GO:0045324 [late endosome to vacuole transport]
GO:0046761 [viral budding from plasma membrane]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051469 [vesicle fusion with vacuole]
GO:0060548 [negative regulation of cell death]
GO:0061763 [multivesicular body-lysosome fusion]
GO:0061952 [midbody abscission]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:0090148 [membrane fission]
GO:0097352 [autophagosome maturation]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902774 [late endosome to lysosome transport]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903723 [negative regulation of centriole elongation]
GO:1904903 [ESCRT III complex disassembly]
GO:1904930 [amphisome membrane]
Show all
 222 aa
25.1 kDa 		No 0
CHMP2A-204
ENSP00000469453
ENST00000597848
O43633
[Direct mapping] Charged multivesicular body protein 2a
Show all
M0QXX8
[Direct mapping] Charged multivesicular body protein 2a
A0A024R4S0
[Target identity:100%; Query identity:100%] Chromatin modifying protein 2A, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000421 [autophagosome membrane]
GO:0000776 [kinetochore]
GO:0000785 [chromatin]
GO:0000815 [ESCRT III complex]
GO:0001778 [plasma membrane repair]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005771 [multivesicular body]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006914 [autophagy]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0008333 [endosome to lysosome transport]
GO:0010324 [membrane invagination]
GO:0010458 [exit from mitosis]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019076 [viral release from host cell]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0030496 [midbody]
GO:0031210 [phosphatidylcholine binding]
GO:0031468 [nuclear membrane reassembly]
GO:0031902 [late endosome membrane]
GO:0032509 [endosome transport via multivesicular body sorting pathway]
GO:0032585 [multivesicular body membrane]
GO:0036258 [multivesicular body assembly]
GO:0039702 [viral budding via host ESCRT complex]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045184 [establishment of protein localization]
GO:0045324 [late endosome to vacuole transport]
GO:0046761 [viral budding from plasma membrane]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051469 [vesicle fusion with vacuole]
GO:0060548 [negative regulation of cell death]
GO:0061763 [multivesicular body-lysosome fusion]
GO:0061952 [midbody abscission]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:0090148 [membrane fission]
GO:0097352 [autophagosome maturation]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902774 [late endosome to lysosome transport]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903723 [negative regulation of centriole elongation]
GO:1904903 [ESCRT III complex disassembly]
GO:1904930 [amphisome membrane]
Show all
 222 aa
25.1 kDa 		No 0
CHMP2A-205
ENSP00000472097
ENST00000600006
M0R1T5
[Direct mapping] Charged multivesicular body protein 2a
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000776 [kinetochore]
GO:0001778 [plasma membrane repair]
GO:0005643 [nuclear pore]
GO:0005765 [lysosomal membrane]
GO:0005828 [kinetochore microtubule]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0008333 [endosome to lysosome transport]
GO:0030496 [midbody]
GO:0031468 [nuclear membrane reassembly]
GO:0032585 [multivesicular body membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0046761 [viral budding from plasma membrane]
GO:0060548 [negative regulation of cell death]
GO:0061952 [midbody abscission]
GO:0090148 [membrane fission]
GO:0097352 [autophagosome maturation]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902774 [late endosome to lysosome transport]
GO:1904930 [amphisome membrane]
Show all
 265 aa
29.6 kDa 		No 0
CHMP2A-206
ENSP00000469240
ENST00000600118
O43633
[Direct mapping] Charged multivesicular body protein 2a
Show all
A0A024R4S0
[Target identity:100%; Query identity:100%] Chromatin modifying protein 2A, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000421 [autophagosome membrane]
GO:0000776 [kinetochore]
GO:0000785 [chromatin]
GO:0000815 [ESCRT III complex]
GO:0001778 [plasma membrane repair]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005771 [multivesicular body]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006914 [autophagy]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0008333 [endosome to lysosome transport]
GO:0010324 [membrane invagination]
GO:0010458 [exit from mitosis]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019076 [viral release from host cell]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0030496 [midbody]
GO:0031210 [phosphatidylcholine binding]
GO:0031468 [nuclear membrane reassembly]
GO:0031902 [late endosome membrane]
GO:0032509 [endosome transport via multivesicular body sorting pathway]
GO:0032585 [multivesicular body membrane]
GO:0036258 [multivesicular body assembly]
GO:0039702 [viral budding via host ESCRT complex]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045184 [establishment of protein localization]
GO:0045324 [late endosome to vacuole transport]
GO:0046761 [viral budding from plasma membrane]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051469 [vesicle fusion with vacuole]
GO:0060548 [negative regulation of cell death]
GO:0061763 [multivesicular body-lysosome fusion]
GO:0061952 [midbody abscission]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:0090148 [membrane fission]
GO:0097352 [autophagosome maturation]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902774 [late endosome to lysosome transport]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903723 [negative regulation of centriole elongation]
GO:1904903 [ESCRT III complex disassembly]
GO:1904930 [amphisome membrane]
Show all
 222 aa
25.1 kDa 		No 0
CHMP2A-208
ENSP00000472680
ENST00000601220
O43633
[Direct mapping] Charged multivesicular body protein 2a
Show all
A0A024R4S0
[Target identity:100%; Query identity:100%] Chromatin modifying protein 2A, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000421 [autophagosome membrane]
GO:0000776 [kinetochore]
GO:0000785 [chromatin]
GO:0000815 [ESCRT III complex]
GO:0001778 [plasma membrane repair]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005771 [multivesicular body]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006914 [autophagy]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0008333 [endosome to lysosome transport]
GO:0010324 [membrane invagination]
GO:0010458 [exit from mitosis]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019076 [viral release from host cell]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0030496 [midbody]
GO:0031210 [phosphatidylcholine binding]
GO:0031468 [nuclear membrane reassembly]
GO:0031902 [late endosome membrane]
GO:0032509 [endosome transport via multivesicular body sorting pathway]
GO:0032585 [multivesicular body membrane]
GO:0036258 [multivesicular body assembly]
GO:0039702 [viral budding via host ESCRT complex]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045184 [establishment of protein localization]
GO:0045324 [late endosome to vacuole transport]
GO:0046761 [viral budding from plasma membrane]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051469 [vesicle fusion with vacuole]
GO:0060548 [negative regulation of cell death]
GO:0061763 [multivesicular body-lysosome fusion]
GO:0061952 [midbody abscission]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:0090148 [membrane fission]
GO:0097352 [autophagosome maturation]
GO:1901673 [regulation of mitotic spindle assembly]
GO:1902774 [late endosome to lysosome transport]
GO:1903543 [positive regulation of exosomal secretion]
GO:1903723 [negative regulation of centriole elongation]
GO:1904903 [ESCRT III complex disassembly]
GO:1904930 [amphisome membrane]
Show all
 222 aa
25.1 kDa 		No 0

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