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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p35.3
Chromosome location (bp)
28259518 - 28282491
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex 1,2,3,4,5,6,7,8,9,10. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling 11,12,13,14,15,16,17,18,19,20. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway 21,22,23,24,25. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 26. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 27. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress 28. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein 29. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 30. However, this could not be confirmed 31....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001932[regulation of protein phosphorylation] GO:0004601[peroxidase activity] GO:0005092[GDP-dissociation inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006111[regulation of gluconeogenesis] GO:0006635[fatty acid beta-oxidation] GO:0007005[mitochondrion organization] GO:0009749[response to glucose] GO:0016239[positive regulation of macroautophagy] GO:0016491[oxidoreductase activity] GO:0016684[oxidoreductase activity, acting on peroxide as acceptor] GO:0030308[negative regulation of cell growth] GO:0030330[DNA damage response, signal transduction by p53 class mediator] GO:0031588[nucleotide-activated protein kinase complex] GO:0031932[TORC2 complex] GO:0032042[mitochondrial DNA metabolic process] GO:0032147[activation of protein kinase activity] GO:0032542[sulfiredoxin activity] GO:0032868[response to insulin] GO:0034198[cellular response to amino acid starvation] GO:0034599[cellular response to oxidative stress] GO:0042149[cellular response to glucose starvation] GO:0042593[glucose homeostasis] GO:0042731[PH domain binding] GO:0043491[protein kinase B signaling] GO:0044877[protein-containing complex binding] GO:0046323[glucose import] GO:0051716[cellular response to stimulus] GO:0070328[triglyceride homeostasis] GO:0070728[leucine binding] GO:0071230[cellular response to amino acid stimulus] GO:0071233[cellular response to leucine] GO:0072593[reactive oxygen species metabolic process] GO:0098869[cellular oxidant detoxification] GO:0140311[protein sequestering activity] GO:1900182[positive regulation of protein localization to nucleus] GO:1901031[regulation of response to reactive oxygen species] GO:1902010[negative regulation of translation in response to endoplasmic reticulum stress] GO:1904262[negative regulation of TORC1 signaling] GO:1904504[positive regulation of lipophagy] GO:1990253[cellular response to leucine starvation] GO:1990316[Atg1/ULK1 kinase complex] GO:2000479[regulation of cAMP-dependent protein kinase activity]
The Human Protein Atlas project is funded
