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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p35.3
Chromosome location (bp)
28236109 - 28246906
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Primary Active Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001937[negative regulation of endothelial cell proliferation] GO:0004857[enzyme inhibitor activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005739[mitochondrion] GO:0006091[generation of precursor metabolites and energy] GO:0006783[heme biosynthetic process] GO:0009986[cell surface] GO:0019899[enzyme binding] GO:0030218[erythrocyte differentiation] GO:0032780[negative regulation of ATP-dependent activity] GO:0032991[protein-containing complex] GO:0042030[ATPase inhibitor activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043532[angiostatin binding] GO:0051117[ATPase binding] GO:0051346[negative regulation of hydrolase activity] GO:0051882[mitochondrial depolarization] GO:0072593[reactive oxygen species metabolic process] GO:0140260[mitochondrial proton-transporting ATP synthase complex binding] GO:1901030[positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1903052[positive regulation of proteolysis involved in protein catabolic process] GO:1903214[regulation of protein targeting to mitochondrion] GO:1903578[regulation of ATP metabolic process] GO:1904925[positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization]
Transporters Primary Active Transporters DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001937[negative regulation of endothelial cell proliferation] GO:0004857[enzyme inhibitor activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005739[mitochondrion] GO:0006091[generation of precursor metabolites and energy] GO:0006783[heme biosynthetic process] GO:0009986[cell surface] GO:0019899[enzyme binding] GO:0030218[erythrocyte differentiation] GO:0032780[negative regulation of ATP-dependent activity] GO:0032991[protein-containing complex] GO:0042030[ATPase inhibitor activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043532[angiostatin binding] GO:0051117[ATPase binding] GO:0051346[negative regulation of hydrolase activity] GO:0051882[mitochondrial depolarization] GO:0140260[mitochondrial proton-transporting ATP synthase complex binding] GO:1903052[positive regulation of proteolysis involved in protein catabolic process] GO:1903214[regulation of protein targeting to mitochondrion] GO:1903578[regulation of ATP metabolic process] GO:1904925[positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization]
A0A0B4J230 [Direct mapping] ATP synthase F1 subunit epsilon
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0005739[mitochondrion] GO:0032780[negative regulation of ATP-dependent activity] GO:0042030[ATPase inhibitor activity]
Transporters Primary Active Transporters DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001937[negative regulation of endothelial cell proliferation] GO:0004857[enzyme inhibitor activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005739[mitochondrion] GO:0006091[generation of precursor metabolites and energy] GO:0006783[heme biosynthetic process] GO:0009986[cell surface] GO:0019899[enzyme binding] GO:0030218[erythrocyte differentiation] GO:0032780[negative regulation of ATP-dependent activity] GO:0032991[protein-containing complex] GO:0042030[ATPase inhibitor activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043532[angiostatin binding] GO:0051117[ATPase binding] GO:0051346[negative regulation of hydrolase activity] GO:0051882[mitochondrial depolarization] GO:0140260[mitochondrial proton-transporting ATP synthase complex binding] GO:1903052[positive regulation of proteolysis involved in protein catabolic process] GO:1903214[regulation of protein targeting to mitochondrion] GO:1903578[regulation of ATP metabolic process] GO:1904925[positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization]
The Human Protein Atlas project is funded
