We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q25.1
Chromosome location (bp)
149658153 - 149718105
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082[G1/S transition of mitotic cell cycle] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000278[mitotic cell cycle] GO:0000287[magnesium ion binding] GO:0000819[sister chromatid segregation] GO:0000922[spindle pole] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007049[cell cycle] GO:0009755[hormone-mediated signaling pathway] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0017015[regulation of transforming growth factor beta receptor signaling pathway] GO:0018105[peptidyl-serine phosphorylation] GO:0019901[protein kinase binding] GO:0030331[nuclear estrogen receptor binding] GO:0030496[midbody] GO:0030833[regulation of actin filament polymerization] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033146[regulation of intracellular estrogen receptor signaling pathway] GO:0035329[hippo signaling] GO:0035556[intracellular signal transduction] GO:0043065[positive regulation of apoptotic process] GO:0043254[regulation of protein-containing complex assembly] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0046620[regulation of organ growth] GO:0046872[metal ion binding] GO:0051220[cytoplasmic sequestering of protein] GO:0051301[cell division] GO:0060644[mammary gland epithelial cell differentiation] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0106310[protein serine kinase activity] GO:1900181[negative regulation of protein localization to nucleus] GO:2000058[regulation of ubiquitin-dependent protein catabolic process]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082[G1/S transition of mitotic cell cycle] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000278[mitotic cell cycle] GO:0000287[magnesium ion binding] GO:0000819[sister chromatid segregation] GO:0000922[spindle pole] GO:0001827[inner cell mass cell fate commitment] GO:0001828[inner cell mass cellular morphogenesis] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005815[microtubule organizing center] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007049[cell cycle] GO:0008104[protein localization] GO:0009755[hormone-mediated signaling pathway] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0017015[regulation of transforming growth factor beta receptor signaling pathway] GO:0018105[peptidyl-serine phosphorylation] GO:0019901[protein kinase binding] GO:0030216[keratinocyte differentiation] GO:0030331[nuclear estrogen receptor binding] GO:0030496[midbody] GO:0030833[regulation of actin filament polymerization] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033146[regulation of intracellular estrogen receptor signaling pathway] GO:0035329[hippo signaling] GO:0035556[intracellular signal transduction] GO:0043065[positive regulation of apoptotic process] GO:0043254[regulation of protein-containing complex assembly] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0046620[regulation of organ growth] GO:0046872[metal ion binding] GO:0051220[cytoplasmic sequestering of protein] GO:0051301[cell division] GO:0060644[mammary gland epithelial cell differentiation] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0106310[protein serine kinase activity] GO:1900181[negative regulation of protein localization to nucleus] GO:2000058[regulation of ubiquitin-dependent protein catabolic process]
The Human Protein Atlas project is funded
