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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.4
Chromosome location (bp)
4384897 - 4393702
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2 1,2,3,4,5,6,7,8,9,10. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination 11,12. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes 13. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome 14. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling 15. Negatively regulates IFN-beta production post-pathogen recognition by catalyzing polyubiquitin-mediated degradation of IRF3 16. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway 17. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages (By similarity). Plays a role in the regulation of the cell cycle progression 18. Enhances the decapping activity of DCP2 19. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules 20,21. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified 22. The common feature of these proteins is their ability to bind HY RNAs.2 23. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma 24. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy 25. Regulates also autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability 26. Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'- linked ubiquitination of NMI 27. During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation 28. When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity 29. Mediates 'Lys-63'- linked polyubiquitination of G3BP1 in response to heat shock, leading to stress granule disassembly 30....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0000932[P-body] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005776[autophagosome] GO:0005829[cytosol] GO:0006513[protein monoubiquitination] GO:0007049[cell cycle] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019005[SCF ubiquitin ligase complex] GO:0019901[protein kinase binding] GO:0031410[cytoplasmic vesicle] GO:0031648[protein destabilization] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032092[positive regulation of protein binding] GO:0032479[regulation of type I interferon production] GO:0032880[regulation of protein localization] GO:0032897[negative regulation of viral transcription] GO:0034341[response to type II interferon] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044790[suppression of viral release by host] GO:0045087[innate immune response] GO:0045787[positive regulation of cell cycle] GO:0045824[negative regulation of innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0046596[regulation of viral entry into host cell] GO:0046598[positive regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0062197[cellular response to chemical stress] GO:0070534[protein K63-linked ubiquitination] GO:0090086[negative regulation of protein deubiquitination] GO:1990904[ribonucleoprotein complex]
The Human Protein Atlas project is funded
