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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p25.2
Chromosome location (bp)
12287368 - 12434356
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001890[placenta development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0004955[prostaglandin receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007154[cell communication] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007584[response to nutrient] GO:0008022[protein C-terminus binding] GO:0008217[regulation of blood pressure] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010742[macrophage derived foam cell differentiation] GO:0010745[negative regulation of macrophage derived foam cell differentiation] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010875[positive regulation of cholesterol efflux] GO:0010887[negative regulation of cholesterol storage] GO:0010888[negative regulation of lipid storage] GO:0010891[negative regulation of sequestering of triglyceride] GO:0015909[long-chain fatty acid transport] GO:0016525[negative regulation of angiogenesis] GO:0019216[regulation of lipid metabolic process] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030224[monocyte differentiation] GO:0030509[BMP signaling pathway] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030514[negative regulation of BMP signaling pathway] GO:0030855[epithelial cell differentiation] GO:0032869[cellular response to insulin stimulus] GO:0033993[response to lipid] GO:0035357[peroxisome proliferator activated receptor signaling pathway] GO:0042277[peptide binding] GO:0042593[glucose homeostasis] GO:0042752[regulation of circadian rhythm] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042802[identical protein binding] GO:0042953[lipoprotein transport] GO:0043231[intracellular membrane-bounded organelle] GO:0043235[receptor complex] GO:0043388[positive regulation of DNA binding] GO:0043407[negative regulation of MAP kinase activity] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0043621[protein self-association] GO:0045087[innate immune response] GO:0045165[cell fate commitment] GO:0045600[positive regulation of fat cell differentiation] GO:0045668[negative regulation of osteoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045923[positive regulation of fatty acid metabolic process] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046965[nuclear retinoid X receptor binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048469[cell maturation] GO:0048511[rhythmic process] GO:0048662[negative regulation of smooth muscle cell proliferation] GO:0050544[arachidonic acid binding] GO:0050692[DNA binding domain binding] GO:0050693[LBD domain binding] GO:0050728[negative regulation of inflammatory response] GO:0050872[white fat cell differentiation] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051393[alpha-actinin binding] GO:0051716[cellular response to stimulus] GO:0055088[lipid homeostasis] GO:0060336[negative regulation of interferon-gamma-mediated signaling pathway] GO:0060391[positive regulation of SMAD protein signal transduction] GO:0060392[negative regulation of SMAD protein signal transduction] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0060694[regulation of cholesterol transporter activity] GO:0060965[negative regulation of miRNA-mediated gene silencing] GO:0070165[positive regulation of adiponectin secretion] GO:0070412[R-SMAD binding] GO:0070888[E-box binding] GO:0071404[cellular response to low-density lipoprotein particle stimulus] GO:0071456[cellular response to hypoxia] GO:0090258[negative regulation of mitochondrial fission] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097677[STAT family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1900076[regulation of cellular response to insulin stimulus] GO:1902894[negative regulation of miRNA transcription] GO:1902895[positive regulation of miRNA transcription] GO:1903243[negative regulation of cardiac muscle hypertrophy in response to stress] GO:1903845[negative regulation of cellular response to transforming growth factor beta stimulus] GO:1904179[positive regulation of adipose tissue development] GO:1904597[negative regulation of connective tissue replacement involved in inflammatory response wound healing] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904893[negative regulation of receptor signaling pathway via STAT] GO:1905461[positive regulation of vascular associated smooth muscle cell apoptotic process] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1905599[positive regulation of low-density lipoprotein receptor activity] GO:2000272[negative regulation of signaling receptor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976[transcription cis-regulatory region binding] GO:0001223[transcription coactivator binding] GO:0002674[negative regulation of acute inflammatory response] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007154[cell communication] GO:0007507[heart development] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0009409[response to cold] GO:0009410[response to xenobiotic stimulus] GO:0009612[response to mechanical stimulus] GO:0010033[response to organic substance] GO:0010629[negative regulation of gene expression] GO:0010888[negative regulation of lipid storage] GO:0014070[response to organic cyclic compound] GO:0019216[regulation of lipid metabolic process] GO:0019395[fatty acid oxidation] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030331[nuclear estrogen receptor binding] GO:0030522[intracellular receptor signaling pathway] GO:0031000[response to caffeine] GO:0031100[animal organ regeneration] GO:0032966[negative regulation of collagen biosynthetic process] GO:0033189[response to vitamin A] GO:0033993[response to lipid] GO:0035902[response to immobilization stress] GO:0042594[response to starvation] GO:0043065[positive regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0043627[response to estrogen] GO:0045598[regulation of fat cell differentiation] GO:0045600[positive regulation of fat cell differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046321[positive regulation of fatty acid oxidation] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0048511[rhythmic process] GO:0048662[negative regulation of smooth muscle cell proliferation] GO:0048714[positive regulation of oligodendrocyte differentiation] GO:0051716[cellular response to stimulus] GO:0051974[negative regulation of telomerase activity] GO:0060100[positive regulation of phagocytosis, engulfment] GO:0070165[positive regulation of adiponectin secretion] GO:0071300[cellular response to retinoic acid] GO:0071306[cellular response to vitamin E] GO:0071379[cellular response to prostaglandin stimulus] GO:0071380[cellular response to prostaglandin E stimulus] GO:0071455[cellular response to hyperoxia] GO:0071456[cellular response to hypoxia] GO:1901558[response to metformin] GO:1903243[negative regulation of cardiac muscle hypertrophy in response to stress] GO:1904597[negative regulation of connective tissue replacement involved in inflammatory response wound healing] GO:2000230[negative regulation of pancreatic stellate cell proliferation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of endocrine organs Congenital disorders of metabolism Other congenital disorders of metabolism Endocrine and metabolic diseases Diabetes Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
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