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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.4
Chromosome location (bp)
5663195 - 5938619
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) 1. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 2. Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction 3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9C035 [Direct mapping] Tripartite motif-containing protein 5
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Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0000932[P-body] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0031664[regulation of lipopolysaccharide-mediated signaling pathway] GO:0032880[regulation of protein localization] GO:0038187[pattern recognition receptor activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043410[positive regulation of MAPK cascade] GO:0044790[suppression of viral release by host] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0046596[regulation of viral entry into host cell] GO:0046597[negative regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051607[defense response to virus] GO:0061630[ubiquitin protein ligase activity] GO:0070534[protein K63-linked ubiquitination] GO:1990462[omegasome]
Q9C035 [Direct mapping] Tripartite motif-containing protein 5
Show all
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0000932[P-body] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0031664[regulation of lipopolysaccharide-mediated signaling pathway] GO:0032880[regulation of protein localization] GO:0038187[pattern recognition receptor activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043410[positive regulation of MAPK cascade] GO:0044790[suppression of viral release by host] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0046596[regulation of viral entry into host cell] GO:0046597[negative regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051607[defense response to virus] GO:0061630[ubiquitin protein ligase activity] GO:0070534[protein K63-linked ubiquitination] GO:1990462[omegasome]
Q9C035 [Direct mapping] Tripartite motif-containing protein 5
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Enzymes ENZYME proteins Transferases Metabolic proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0000932[P-body] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0031664[regulation of lipopolysaccharide-mediated signaling pathway] GO:0032880[regulation of protein localization] GO:0038187[pattern recognition receptor activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043410[positive regulation of MAPK cascade] GO:0044790[suppression of viral release by host] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0046596[regulation of viral entry into host cell] GO:0046597[negative regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051607[defense response to virus] GO:0061630[ubiquitin protein ligase activity] GO:0070534[protein K63-linked ubiquitination] GO:1990462[omegasome]
Q9C035 [Direct mapping] Tripartite motif-containing protein 5
Show all
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0000932[P-body] GO:0002218[activation of innate immune response] GO:0002376[immune system process] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006914[autophagy] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0031664[regulation of lipopolysaccharide-mediated signaling pathway] GO:0032880[regulation of protein localization] GO:0038187[pattern recognition receptor activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043410[positive regulation of MAPK cascade] GO:0044790[suppression of viral release by host] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0046596[regulation of viral entry into host cell] GO:0046597[negative regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051607[defense response to virus] GO:0061630[ubiquitin protein ligase activity] GO:0070534[protein K63-linked ubiquitination] GO:1990462[omegasome]
The Human Protein Atlas project is funded
