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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.2
Chromosome location (bp)
4538897 - 4555386
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001649[osteoblast differentiation] GO:0003677[DNA binding] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0008134[transcription factor binding] GO:0016020[membrane] GO:0022904[respiratory electron transport chain] GO:0032922[circadian regulation of gene expression] GO:0035066[positive regulation of histone acetylation] GO:0042149[cellular response to glucose starvation] GO:0042254[ribosome biogenesis] GO:0042564[NLS-dependent protein nuclear import complex] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045943[positive regulation of transcription by RNA polymerase I] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045945[positive regulation of transcription by RNA polymerase III] GO:0048511[rhythmic process] GO:0070888[E-box binding] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0110016[B-WICH complex] GO:1903450[regulation of G1 to G0 transition] GO:2000210[positive regulation of anoikis]
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649[osteoblast differentiation] GO:0003677[DNA binding] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0008134[transcription factor binding] GO:0016020[membrane] GO:0032922[circadian regulation of gene expression] GO:0035066[positive regulation of histone acetylation] GO:0042149[cellular response to glucose starvation] GO:0042254[ribosome biogenesis] GO:0042564[NLS-dependent protein nuclear import complex] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045943[positive regulation of transcription by RNA polymerase I] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045945[positive regulation of transcription by RNA polymerase III] GO:0048511[rhythmic process] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0110016[B-WICH complex] GO:1903450[regulation of G1 to G0 transition] GO:2000210[positive regulation of anoikis]
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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