GENERAL INFORMATIONi
Gene namei DLG4
Synonyms PSD-95, PSD95, SAP-90, SAP90
Gene descriptioni Discs large MAGUK scaffold protein 4
Protein classi Disease related genes
Human disease related genes
Potential drug targets
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 17
Cytoband p13.1
Chromosome location (bp) 7187187 - 7219841
Number of transcriptsi 19
Ensembl ENSG00000132535 (version 109)
Entrez gene 1742
HGNC HGNC:2903
UniProt P78352 (UniProt - Evidence at protein level)
neXtProt NX_P78352
GeneCards DLG4
Antibodypedia DLG4 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins 1. show less
Gene summary (Entrez)i This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
DLG4-201
ENSP00000307471
ENST00000302955
P78352
[Direct mapping] Disks large homolog 4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002091 [negative regulation of receptor internalization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [chemical synaptic transmission]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0030863 [cortical cytoskeleton]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0031697 [beta-1 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031812 [P2Y1 nucleotide receptor binding]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032839 [dendrite cytoplasm]
GO:0033130 [acetylcholine receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0035865 [cellular response to potassium ion]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043113 [receptor clustering]
GO:0043197 [dendritic spine]
GO:0044224 [juxtaparanode region of axon]
GO:0044306 [neuron projection terminus]
GO:0044309 [neuron spine]
GO:0044877 [protein-containing complex binding]
GO:0045184 [establishment of protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0050806 [positive regulation of synaptic transmission]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0065003 [protein-containing complex assembly]
GO:0097060 [synaptic membrane]
GO:0097109 [neuroligin family protein binding]
GO:0097110 [scaffold protein binding]
GO:0097113 [AMPA glutamate receptor clustering]
GO:0097120 [receptor localization to synapse]
GO:0098609 [cell-cell adhesion]
GO:0098793 [presynapse]
GO:0098839 [postsynaptic density membrane]
GO:0098970 [postsynaptic neurotransmitter receptor diffusion trapping]
GO:0099562 [maintenance of postsynaptic density structure]
GO:0150012 [positive regulation of neuron projection arborization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 721 aa
80.1 kDa 		No 0
DLG4-202
ENSP00000382425
ENST00000399506
P78352
[Direct mapping] Disks large homolog 4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002091 [negative regulation of receptor internalization]
GO:0005102 [signaling receptor binding]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [chemical synaptic transmission]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0019865 [immunoglobulin binding]
GO:0019894 [kinesin binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0021987 [cerebral cortex development]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0030863 [cortical cytoskeleton]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0031697 [beta-1 adrenergic receptor binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031812 [P2Y1 nucleotide receptor binding]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032839 [dendrite cytoplasm]
GO:0033130 [acetylcholine receptor binding]
GO:0035176 [social behavior]
GO:0035254 [glutamate receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0035641 [locomotory exploration behavior]
GO:0035865 [cellular response to potassium ion]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043113 [receptor clustering]
GO:0043197 [dendritic spine]
GO:0044224 [juxtaparanode region of axon]
GO:0044300 [cerebellar mossy fiber]
GO:0044306 [neuron projection terminus]
GO:0044307 [dendritic branch]
GO:0044309 [neuron spine]
GO:0044877 [protein-containing complex binding]
GO:0045184 [establishment of protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0050806 [positive regulation of synaptic transmission]
GO:0050885 [neuromuscular process controlling balance]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0065003 [protein-containing complex assembly]
GO:0071625 [vocalization behavior]
GO:0071944 [cell periphery]
GO:0097060 [synaptic membrane]
GO:0097061 [dendritic spine organization]
GO:0097109 [neuroligin family protein binding]
GO:0097110 [scaffold protein binding]
GO:0097113 [AMPA glutamate receptor clustering]
GO:0097120 [receptor localization to synapse]
GO:0098609 [cell-cell adhesion]
GO:0098793 [presynapse]
GO:0098794 [postsynapse]
GO:0098839 [postsynaptic density membrane]
GO:0098919 [structural constituent of postsynaptic density]
GO:0098970 [postsynaptic neurotransmitter receptor diffusion trapping]
GO:0098978 [glutamatergic synapse]
GO:0099562 [maintenance of postsynaptic density structure]
GO:0099645 [neurotransmitter receptor localization to postsynaptic specialization membrane]
GO:0150012 [positive regulation of neuron projection arborization]
GO:1904719 [positive regulation of AMPA glutamate receptor clustering]
GO:1990635 [proximal dendrite]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000821 [regulation of grooming behavior]
Show all
 724 aa
80.5 kDa 		No 0
DLG4-203
ENSP00000382428
ENST00000399510
B9EGL1
[Direct mapping] DLG4 protein; Discs, large homolog 4 (Drosophila), isoform CRA_c; Disks large homolog 4
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030054 [cell junction]
Show all
 764 aa
85.1 kDa 		No 0
DLG4-204
ENSP00000388122
ENST00000447163
C9JWP9
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 242 aa
25.9 kDa 		No 0
DLG4-205
ENSP00000407918
ENST00000451807
C9JYG3
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 242 aa
25.8 kDa 		No 0
DLG4-206
ENSP00000460625
ENST00000485100
O14909
[Direct mapping] Discs, large homolog 4 (Drosophila), isoform CRA_d; Disks large homolog 4; Tax interaction protein 15
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 296 aa
31.9 kDa 		No 0
DLG4-207
ENSP00000465720
ENST00000486626
K7EKP9
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 198 aa
21.1 kDa 		No 0
DLG4-210
ENSP00000465789
ENST00000493294
K7EKU8
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 205 aa
21.7 kDa 		No 0
DLG4-211
ENSP00000497912
ENST00000647975
A0A3B3ITI9
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 277 aa
29.7 kDa 		No 0
DLG4-213
ENSP00000497806
ENST00000648172
P78352
[Direct mapping] Disks large homolog 4
Show all
Transporters
   Accessory Factors Involved in Transport
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002091 [negative regulation of receptor internalization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [chemical synaptic transmission]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0019900 [kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0030863 [cortical cytoskeleton]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0031697 [beta-1 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031812 [P2Y1 nucleotide receptor binding]
GO:0032281 [AMPA glutamate receptor complex]
GO:0032839 [dendrite cytoplasm]
GO:0033130 [acetylcholine receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0035865 [cellular response to potassium ion]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043113 [receptor clustering]
GO:0043197 [dendritic spine]
GO:0044224 [juxtaparanode region of axon]
GO:0044306 [neuron projection terminus]
GO:0044309 [neuron spine]
GO:0044877 [protein-containing complex binding]
GO:0045184 [establishment of protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0050806 [positive regulation of synaptic transmission]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0065003 [protein-containing complex assembly]
GO:0097060 [synaptic membrane]
GO:0097109 [neuroligin family protein binding]
GO:0097110 [scaffold protein binding]
GO:0097113 [AMPA glutamate receptor clustering]
GO:0097120 [receptor localization to synapse]
GO:0098609 [cell-cell adhesion]
GO:0098793 [presynapse]
GO:0098839 [postsynaptic density membrane]
GO:0098970 [postsynaptic neurotransmitter receptor diffusion trapping]
GO:0099562 [maintenance of postsynaptic density structure]
GO:0150012 [positive regulation of neuron projection arborization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 767 aa
85.4 kDa 		No 0
DLG4-214
ENSP00000498035
ENST00000648263
A0A3B3IU19
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 487 aa
53.3 kDa 		No 0
DLG4-215
ENSP00000496903
ENST00000648658
A0A3B3IRP2
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 129 aa
14 kDa 		No 0
DLG4-217
ENSP00000497462
ENST00000648760
A0A3B3ISL1
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 51 aa
5.3 kDa 		No 0
DLG4-218
ENSP00000497546
ENST00000648896
A0A3B3ISQ5
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030054 [cell junction]
Show all
 757 aa
84 kDa 		No 0
DLG4-219
ENSP00000497879
ENST00000649186
B7Z647
[Direct mapping] Discs, large homolog 4 (Drosophila), isoform CRA_b; Disks large homolog 4; cDNA FLJ50646, highly similar to Discs large homolog 4; cDNA, FLJ78995, highly similar to Discs large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030054 [cell junction]
Show all
 664 aa
73.9 kDa 		No 0
DLG4-221
ENSP00000497647
ENST00000649520
B7Z647
[Direct mapping] Discs, large homolog 4 (Drosophila), isoform CRA_b; Disks large homolog 4; cDNA FLJ50646, highly similar to Discs large homolog 4; cDNA, FLJ78995, highly similar to Discs large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030054 [cell junction]
Show all
 664 aa
73.9 kDa 		No 0
DLG4-222
ENSP00000497011
ENST00000649971
A0A3B3IS17
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030054 [cell junction]
Show all
 697 aa
77.3 kDa 		No 0
DLG4-223
ENSP00000497553
ENST00000650120
A0A3B3ISR0
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 587 aa
64.7 kDa 		No 0
DLG4-224
ENSP00000497662
ENST00000650301
A0A3B3ITD1
[Direct mapping] Disks large homolog 4
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other diseases
   Mental and behavioural disorders
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.


contact@proteinatlas.org