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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Metabolic proteins RNA polymerase related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
p11.23
Chromosome location (bp)
18466878 - 18484648
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates 1,2,3,4. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer that coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state 5,6,7. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as a nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway 8,9,10. Preferentially binds double-stranded DNA (dsDNA) 11....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9H1D9 [Direct mapping] DNA-directed RNA polymerase III subunit RPC6
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005666[RNA polymerase III complex] GO:0006383[transcription by RNA polymerase III]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
Metabolic proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005666[RNA polymerase III complex] GO:0006383[transcription by RNA polymerase III]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005666[RNA polymerase III complex] GO:0006383[transcription by RNA polymerase III]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005666[RNA polymerase III complex] GO:0006383[transcription by RNA polymerase III]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005666[RNA polymerase III complex] GO:0006383[transcription by RNA polymerase III]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005666[RNA polymerase III complex] GO:0006383[transcription by RNA polymerase III]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005666[RNA polymerase III complex] GO:0006383[transcription by RNA polymerase III]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
