GENERAL INFORMATIONi
Gene namei BMAL1
Synonyms ARNTL, ARNTL1, bHLHe5, JAP3, MOP3, PASD3
Gene descriptioni Basic helix-loop-helix ARNT like 1
Protein classi Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 11
Cytoband p15.3
Chromosome location (bp) 13276652 - 13387266
Number of transcriptsi 12
Ensembl ENSG00000133794 (version 109)
Entrez gene 406
HGNC HGNC:701
UniProt O00327 (UniProt - Evidence at protein level)
neXtProt NX_O00327
GeneCards BMAL1
Antibodypedia BMAL1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repressBMAL1 transcription, respectively.BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'- CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence 1. CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' 2. The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' 3. Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 4. Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). show less
Molecular function (UniProt)i Activator, DNA-binding
Biological process (UniProt)i Biological rhythms, Transcription, Transcription regulation
Gene summary (Entrez)i The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
BMAL1-201
ENSP00000374357
ENST00000389707
O00327
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
A0A140VKD3
[Target identity:100%; Query identity:100%] Testis tissue sperm-binding protein Li 50e
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901985 [positive regulation of protein acetylation]
GO:1990513 [CLOCK-BMAL transcription complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 625 aa
68.7 kDa 		No 0
BMAL1-202
ENSP00000385915
ENST00000401424
O00327
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901985 [positive regulation of protein acetylation]
GO:1990513 [CLOCK-BMAL transcription complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 582 aa
64.1 kDa 		No 0
BMAL1-203
ENSP00000384517
ENST00000403290
O00327
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901985 [positive regulation of protein acetylation]
GO:1990513 [CLOCK-BMAL transcription complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 626 aa
68.8 kDa 		No 0
BMAL1-204
ENSP00000385897
ENST00000403482
O00327
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901985 [positive regulation of protein acetylation]
GO:1990513 [CLOCK-BMAL transcription complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 624 aa
68.8 kDa 		No 0
BMAL1-205
ENSP00000385581
ENST00000403510
O00327
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901985 [positive regulation of protein acetylation]
GO:1990513 [CLOCK-BMAL transcription complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 626 aa
68.8 kDa 		No 0
BMAL1-212
ENSP00000433540
ENST00000527998
E9PKG7
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.4 kDa 		No 0
BMAL1-213
ENSP00000434044
ENST00000529050
E9PSD2
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 23 aa
2.5 kDa 		No 0
BMAL1-214
ENSP00000433571
ENST00000529388
O00327
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901985 [positive regulation of protein acetylation]
GO:1990513 [CLOCK-BMAL transcription complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 626 aa
68.8 kDa 		No 0
BMAL1-218
ENSP00000434781
ENST00000531665
E9PNI4
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.6 kDa 		No 0
BMAL1-219
ENSP00000431488
ENST00000533520
E9PL54
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046983 [protein dimerization activity]
Show all
 100 aa
11.3 kDa 		No 0
BMAL1-221
ENSP00000431566
ENST00000534544
E9PKN1
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.4 kDa 		No 0
BMAL1-223
ENSP00000501212
ENST00000673817
A0A669KBF4
[Direct mapping] Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
Show all
 630 aa
69.2 kDa 		No 0

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