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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q13.2
Chromosome location (bp)
69167135 - 69178245
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Essential for the control of the cell cycle at the G2/M (mitosis) transition....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cyclin
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division, Mitosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Transporter channels and pores SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0000922[spindle pole] GO:0000940[outer kinetochore] GO:0001701[in utero embryonic development] GO:0005113[patched binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007049[cell cycle] GO:0007052[mitotic spindle organization] GO:0007080[mitotic metaphase plate congression] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016020[membrane] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901[protein kinase binding] GO:0044389[ubiquitin-like protein ligase binding] GO:0044772[mitotic cell cycle phase transition] GO:0045787[positive regulation of cell cycle] GO:0045931[positive regulation of mitotic cell cycle] GO:0048146[positive regulation of fibroblast proliferation] GO:0051301[cell division] GO:0051987[positive regulation of attachment of spindle microtubules to kinetochore] GO:0060090[molecular adaptor activity] GO:0061575[cyclin-dependent protein serine/threonine kinase activator activity] GO:0090266[regulation of mitotic cell cycle spindle assembly checkpoint] GO:0097125[cyclin B1-CDK1 complex] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
Transporters Transporter channels and pores SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0000922[spindle pole] GO:0000940[outer kinetochore] GO:0005113[patched binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0007049[cell cycle] GO:0007052[mitotic spindle organization] GO:0007080[mitotic metaphase plate congression] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016538[cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901[protein kinase binding] GO:0044389[ubiquitin-like protein ligase binding] GO:0044772[mitotic cell cycle phase transition] GO:0045931[positive regulation of mitotic cell cycle] GO:0051301[cell division] GO:0051987[positive regulation of attachment of spindle microtubules to kinetochore] GO:0060090[molecular adaptor activity] GO:0061575[cyclin-dependent protein serine/threonine kinase activator activity] GO:0090266[regulation of mitotic cell cycle spindle assembly checkpoint] GO:0097125[cyclin B1-CDK1 complex] GO:1905448[positive regulation of mitochondrial ATP synthesis coupled electron transport]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
