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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p13.2
Chromosome location (bp)
113813811 - 113871753
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules 1,2. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue 3. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue 4. Dephosphorylates the immune system activator SKAP2 5. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production 6. Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy 7. Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 8. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Autophagy, Immunity, Lipid metabolism
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A0B4J1S7 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Protein evidence (Kim et al 2014)
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GO:0002230[positive regulation of defense response to virus by host] GO:0002685[regulation of leukocyte migration] GO:0004725[protein tyrosine phosphatase activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006470[protein dephosphorylation] GO:0009898[cytoplasmic side of plasma membrane] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016311[dephosphorylation] GO:0016791[phosphatase activity] GO:0017124[SH3 domain binding] GO:0019900[kinase binding] GO:0030217[T cell differentiation] GO:0032715[negative regulation of interleukin-6 production] GO:0032717[negative regulation of interleukin-8 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032727[positive regulation of interferon-alpha production] GO:0032728[positive regulation of interferon-beta production] GO:0034141[positive regulation of toll-like receptor 3 signaling pathway] GO:0034145[positive regulation of toll-like receptor 4 signaling pathway] GO:0034157[positive regulation of toll-like receptor 7 signaling pathway] GO:0034165[positive regulation of toll-like receptor 9 signaling pathway] GO:0035644[phosphoanandamide dephosphorylation] GO:0042307[positive regulation of protein import into nucleus] GO:0050730[regulation of peptidyl-tyrosine phosphorylation] GO:0050852[T cell receptor signaling pathway] GO:0050856[regulation of T cell receptor signaling pathway] GO:0050868[negative regulation of T cell activation] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070433[negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071225[cellular response to muramyl dipeptide] GO:0071663[positive regulation of granzyme B production] GO:1900227[positive regulation of NLRP3 inflammasome complex assembly] GO:1901222[regulation of NIK/NF-kappaB signaling] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1903169[regulation of calcium ion transmembrane transport] GO:1903753[negative regulation of p38MAPK cascade] GO:1990782[protein tyrosine kinase binding] GO:2000566[positive regulation of CD8-positive, alpha-beta T cell proliferation]
E9PMT0 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases
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GO:0004725[protein tyrosine phosphatase activity] GO:0006470[protein dephosphorylation] GO:0016311[dephosphorylation] GO:0016791[phosphatase activity] GO:0050856[regulation of T cell receptor signaling pathway]
Q9Y2R2 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0002230[positive regulation of defense response to virus by host] GO:0002376[immune system process] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0006629[lipid metabolic process] GO:0006914[autophagy] GO:0009898[cytoplasmic side of plasma membrane] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017124[SH3 domain binding] GO:0019900[kinase binding] GO:0030217[T cell differentiation] GO:0031625[ubiquitin protein ligase binding] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032481[positive regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0032715[negative regulation of interleukin-6 production] GO:0032717[negative regulation of interleukin-8 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032817[regulation of natural killer cell proliferation] GO:0034141[positive regulation of toll-like receptor 3 signaling pathway] GO:0034145[positive regulation of toll-like receptor 4 signaling pathway] GO:0034157[positive regulation of toll-like receptor 7 signaling pathway] GO:0034165[positive regulation of toll-like receptor 9 signaling pathway] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0035644[phosphoanandamide dephosphorylation] GO:0043508[negative regulation of JUN kinase activity] GO:0045088[regulation of innate immune response] GO:0048471[perinuclear region of cytoplasm] GO:0050852[T cell receptor signaling pathway] GO:0050855[regulation of B cell receptor signaling pathway] GO:0050856[regulation of T cell receptor signaling pathway] GO:0050860[negative regulation of T cell receptor signaling pathway] GO:0050868[negative regulation of T cell activation] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070433[negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071225[cellular response to muramyl dipeptide] GO:0071663[positive regulation of granzyme B production] GO:1900227[positive regulation of NLRP3 inflammasome complex assembly] GO:1901222[regulation of NIK/NF-kappaB signaling] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1903753[negative regulation of p38MAPK cascade] GO:2000566[positive regulation of CD8-positive, alpha-beta T cell proliferation]
A0A0A0MTD9 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases
A0A0A0MTE6 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Protein evidence (Kim et al 2014)
F5H2S8 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases
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GO:0004725[protein tyrosine phosphatase activity] GO:0006470[protein dephosphorylation] GO:0016311[dephosphorylation] GO:0016791[phosphatase activity] GO:0050856[regulation of T cell receptor signaling pathway]
The Human Protein Atlas project is funded
