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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Rho associated coiled-coil containing protein kinase 2
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p25.1
Chromosome location (bp)
11179759 - 11348330
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O75116 [Direct mapping] Rho-associated protein kinase 2
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A0A2P9DU05 [Target identity:100%; Query identity:100%] Rho-associated protein kinase
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000281[mitotic cytokinesis] GO:0001837[epithelial to mesenchymal transition] GO:0001934[positive regulation of protein phosphorylation] GO:0002931[response to ischemia] GO:0003180[aortic valve morphogenesis] GO:0003723[RNA binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005198[structural molecule activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006939[smooth muscle contraction] GO:0006996[organelle organization] GO:0007165[signal transduction] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007266[Rho protein signal transduction] GO:0010595[positive regulation of endothelial cell migration] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010825[positive regulation of centrosome duplication] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016525[negative regulation of angiogenesis] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0030036[actin cytoskeleton organization] GO:0030155[regulation of cell adhesion] GO:0030335[positive regulation of cell migration] GO:0030866[cortical actin cytoskeleton organization] GO:0031032[actomyosin structure organization] GO:0031267[small GTPase binding] GO:0031644[regulation of nervous system process] GO:0032723[positive regulation of connective tissue growth factor production] GO:0032956[regulation of actin cytoskeleton organization] GO:0035509[negative regulation of myosin-light-chain-phosphatase activity] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0042752[regulation of circadian rhythm] GO:0043410[positive regulation of MAPK cascade] GO:0044788[modulation by host of viral process] GO:0045019[negative regulation of nitric oxide biosynthetic process] GO:0045616[regulation of keratinocyte differentiation] GO:0046872[metal ion binding] GO:0048156[tau protein binding] GO:0048511[rhythmic process] GO:0048598[embryonic morphogenesis] GO:0050321[tau-protein kinase activity] GO:0051246[regulation of protein metabolic process] GO:0051298[centrosome duplication] GO:0051492[regulation of stress fiber assembly] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0061157[mRNA destabilization] GO:0070168[negative regulation of biomineral tissue development] GO:0071394[cellular response to testosterone stimulus] GO:0071559[response to transforming growth factor beta] GO:0072518[Rho-dependent protein serine/threonine kinase activity] GO:0072659[protein localization to plasma membrane] GO:0090271[positive regulation of fibroblast growth factor production] GO:0097746[blood vessel diameter maintenance] GO:0106310[protein serine kinase activity] GO:0110061[regulation of angiotensin-activated signaling pathway] GO:0150033[negative regulation of protein localization to lysosome] GO:1900037[regulation of cellular response to hypoxia] GO:1901888[regulation of cell junction assembly] GO:1902004[positive regulation of amyloid-beta formation] GO:1902961[positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902966[positive regulation of protein localization to early endosome] GO:1902993[positive regulation of amyloid precursor protein catabolic process] GO:1903140[regulation of establishment of endothelial barrier] GO:1903347[negative regulation of bicellular tight junction assembly] GO:1905145[cellular response to acetylcholine] GO:1905205[positive regulation of connective tissue replacement] GO:1990776[response to angiotensin] GO:2000114[regulation of establishment of cell polarity] GO:2000145[regulation of cell motility]
E9PF63 [Direct mapping] Rho-associated protein kinase 2
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
C9JFJ0 [Direct mapping] Rho-associated protein kinase 2
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MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005524[ATP binding] GO:0006468[protein phosphorylation] GO:0006939[smooth muscle contraction] GO:0007165[signal transduction] GO:0007266[Rho protein signal transduction] GO:0010825[positive regulation of centrosome duplication] GO:0031267[small GTPase binding] GO:0032956[regulation of actin cytoskeleton organization]
The Human Protein Atlas project is funded
