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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes CD markers Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q11.2
Chromosome location (bp)
55935095 - 55995022
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Signal-transducing molecule 1. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways 2,3,4. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 5,6,7. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR 8. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
CD markers MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations Candidate cardiovascular disease genes Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002675[positive regulation of acute inflammatory response] GO:0002821[positive regulation of adaptive immune response] GO:0004896[cytokine receptor activity] GO:0004897[ciliary neurotrophic factor receptor activity] GO:0004915[interleukin-6 receptor activity] GO:0004923[leukemia inhibitory factor receptor activity] GO:0004924[oncostatin-M receptor activity] GO:0005127[ciliary neurotrophic factor receptor binding] GO:0005138[interleukin-6 receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0005896[interleukin-6 receptor complex] GO:0005900[oncostatin-M receptor complex] GO:0008284[positive regulation of cell population proliferation] GO:0009897[external side of plasma membrane] GO:0010575[positive regulation of vascular endothelial growth factor production] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0016020[membrane] GO:0019221[cytokine-mediated signaling pathway] GO:0019838[growth factor binding] GO:0019955[cytokine binding] GO:0019981[interleukin-6 binding] GO:0034097[response to cytokine] GO:0038154[interleukin-11-mediated signaling pathway] GO:0038165[oncostatin-M-mediated signaling pathway] GO:0042102[positive regulation of T cell proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043235[receptor complex] GO:0043524[negative regulation of neuron apoptotic process] GO:0045121[membrane raft] GO:0045509[interleukin-27 receptor activity] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0048861[leukemia inhibitory factor signaling pathway] GO:0060576[intestinal epithelial cell development] GO:0070062[extracellular exosome] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070104[negative regulation of interleukin-6-mediated signaling pathway] GO:0070106[interleukin-27-mediated signaling pathway] GO:0070110[ciliary neurotrophic factor receptor complex] GO:0070120[ciliary neurotrophic factor-mediated signaling pathway] GO:0097110[scaffold protein binding] GO:1901731[positive regulation of platelet aggregation]
The Human Protein Atlas project is funded
