Expression of RPS15A in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPS15A is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1300.82

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

1827.1

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	6167.3
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	4114.6
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	3745.4
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	3611.2
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	3574.6
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	3558.8
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	3531.0
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	3520.7
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	3468.4
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	3406.6
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	3405.7
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	3350.3
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	3184.7
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	3145.3
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	3125.9
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	3088.8
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	3086.1
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	3009.2
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	2952.0
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	2914.3
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	2871.3
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2836.5
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	2801.9
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	2799.7
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	2679.9
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	2613.6
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	2574.7
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	2549.0
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	2542.8
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	2515.8
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	2514.9
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	2504.7
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	2484.3
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	2472.9
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2441.7
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	2437.3
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	2407.0
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	2400.8
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	2396.6
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	2388.2
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	2333.3
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	2328.2
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	2296.2
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	2294.9
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	2282.1
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	2271.2
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	2255.5
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	2233.0
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	2226.5
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	2221.3
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	2193.2
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	2186.0
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	2166.0
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	2106.5
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	2106.0
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2081.2
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	2072.7
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	2070.0
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	2057.5
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	2050.9
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	2032.3
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	2014.2
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	1986.6
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	1968.0
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	1960.4
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	1886.4
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	1879.3
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	1872.4
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	1855.3
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	1847.7
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	1834.9
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	1821.5
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	1819.1
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	1812.9
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	1781.4
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	1779.7
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1779.2
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	1773.0
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	1763.1
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	1756.9
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	1742.0
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	1739.6
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	1703.4
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	1698.4
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	1667.7
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1663.7
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	1656.5
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	1653.6
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	1649.9
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	1641.6
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	1639.6
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	1632.8
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	1593.3
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	1586.1
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	1567.1
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	1552.4
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	1549.6
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	1546.9
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	1520.5
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	1512.3
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	1512.2
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	1508.7
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	1499.2
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	1474.1
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	1469.1
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	1464.1
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	1459.4
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	1449.2
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	1436.6
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	1420.8
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	1398.5
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	1380.0
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	1376.5
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	1367.7
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	1334.0
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	1324.2
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	1323.4
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	1322.9
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	1313.9
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	1305.6
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	1296.1
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	1293.1
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	1292.8
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	1292.6
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	1288.5
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	1285.5
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	1273.2
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	1272.8
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	1258.0
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	1218.9
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	1186.8
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	1175.7
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	1170.9
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	1158.5
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	1158.5
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	1153.4
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	1153.1
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	1150.9
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	1148.8
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	1123.9
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	1122.4
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1104.2
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	1094.8
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	1083.9
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	1071.5
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	1018.4
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1006.2
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	1001.0
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	969.9
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	928.8
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	915.2
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	910.2
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	825.5
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	824.5
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	781.5
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	694.4
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	653.4
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	645.7
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	609.8
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	589.4
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	492.4
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	458.7
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	448.4
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	441.9
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	411.8
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	398.1
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	359.0
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	357.3
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	311.1
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA047103
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade