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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q22.2
Chromosome location (bp)
112707498 - 112846239
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)- induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton 1. Plays a role in mediating the organization of F-actin into ordered bundles 2. Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Wnt signaling pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P25054 [Direct mapping] Adenomatous polyposis coli protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000281[mitotic cytokinesis] GO:0000776[kinetochore] GO:0001708[cell fate specification] GO:0003170[heart valve development] GO:0003203[endocardial cushion morphogenesis] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005881[cytoplasmic microtubule] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0006974[cellular response to DNA damage stimulus] GO:0007026[negative regulation of microtubule depolymerization] GO:0007094[mitotic spindle assembly checkpoint signaling] GO:0007155[cell adhesion] GO:0007389[pattern specification process] GO:0007399[nervous system development] GO:0008013[beta-catenin binding] GO:0008017[microtubule binding] GO:0008285[negative regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0010942[positive regulation of cell death] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016328[lateral plasma membrane] GO:0016342[catenin complex] GO:0016477[cell migration] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030027[lamellipodium] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030335[positive regulation of cell migration] GO:0030877[beta-catenin destruction complex] GO:0031274[positive regulation of pseudopodium assembly] GO:0031625[ubiquitin protein ligase binding] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0042995[cell projection] GO:0043065[positive regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045295[gamma-catenin binding] GO:0045595[regulation of cell differentiation] GO:0045732[positive regulation of protein catabolic process] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0048471[perinuclear region of cytoplasm] GO:0051010[microtubule plus-end binding] GO:0051726[regulation of cell cycle] GO:0051988[regulation of attachment of spindle microtubules to kinetochore] GO:0065003[protein-containing complex assembly] GO:0070161[anchoring junction] GO:0070830[bicellular tight junction assembly] GO:0070840[dynein complex binding] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:1904781[positive regulation of protein localization to centrosome] GO:1990909[Wnt signalosome] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
R4GMU6 [Direct mapping] Adenomatous polyposis coli protein
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
A0A2Q2SV78 [Direct mapping] Adenomatous polyposis coli protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
P25054 [Direct mapping] Adenomatous polyposis coli protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000281[mitotic cytokinesis] GO:0000776[kinetochore] GO:0001708[cell fate specification] GO:0003170[heart valve development] GO:0003203[endocardial cushion morphogenesis] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005881[cytoplasmic microtubule] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0006974[cellular response to DNA damage stimulus] GO:0007026[negative regulation of microtubule depolymerization] GO:0007094[mitotic spindle assembly checkpoint signaling] GO:0007155[cell adhesion] GO:0007389[pattern specification process] GO:0007399[nervous system development] GO:0008013[beta-catenin binding] GO:0008017[microtubule binding] GO:0008285[negative regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0010942[positive regulation of cell death] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016328[lateral plasma membrane] GO:0016342[catenin complex] GO:0016477[cell migration] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030027[lamellipodium] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030335[positive regulation of cell migration] GO:0030877[beta-catenin destruction complex] GO:0031274[positive regulation of pseudopodium assembly] GO:0031625[ubiquitin protein ligase binding] GO:0032587[ruffle membrane] GO:0032886[regulation of microtubule-based process] GO:0042995[cell projection] GO:0043065[positive regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045295[gamma-catenin binding] GO:0045595[regulation of cell differentiation] GO:0045732[positive regulation of protein catabolic process] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0048471[perinuclear region of cytoplasm] GO:0051010[microtubule plus-end binding] GO:0051726[regulation of cell cycle] GO:0051988[regulation of attachment of spindle microtubules to kinetochore] GO:0065003[protein-containing complex assembly] GO:0070161[anchoring junction] GO:0070830[bicellular tight junction assembly] GO:0070840[dynein complex binding] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:1904781[positive regulation of protein localization to centrosome] GO:1990909[Wnt signalosome] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
D6RFL6 [Direct mapping] Adenomatous polyposis coli protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000281[mitotic cytokinesis] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006974[cellular response to DNA damage stimulus] GO:0007026[negative regulation of microtubule depolymerization] GO:0008013[beta-catenin binding] GO:0008285[negative regulation of cell population proliferation] GO:0016477[cell migration] GO:0030178[negative regulation of Wnt signaling pathway] GO:0043065[positive regulation of apoptotic process] GO:0051726[regulation of cell cycle]
E9PFT7 [Direct mapping] Adenomatous polyposis coli protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of eye, brain, and central nervous system Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
