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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
Chromosome location (bp)
36296288 - 36465204
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton 1. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration 2. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress 3. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Signal transduction inhibitor
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; positive regulation of mRNA catabolic process; and regulation of fibroblast migration. Part of TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q6MZQ0 [Direct mapping] Proline-rich protein 5-like
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001933[negative regulation of protein phosphorylation] GO:0005515[protein binding] GO:0009968[negative regulation of signal transduction] GO:0010762[regulation of fibroblast migration] GO:0031625[ubiquitin protein ligase binding] GO:0031932[TORC2 complex] GO:0034599[cellular response to oxidative stress] GO:0038203[TORC2 signaling] GO:0061014[positive regulation of mRNA catabolic process] GO:0090316[positive regulation of intracellular protein transport]
Q6MZQ0 [Direct mapping] Proline-rich protein 5-like
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001933[negative regulation of protein phosphorylation] GO:0005515[protein binding] GO:0009968[negative regulation of signal transduction] GO:0010762[regulation of fibroblast migration] GO:0031625[ubiquitin protein ligase binding] GO:0031932[TORC2 complex] GO:0034599[cellular response to oxidative stress] GO:0038203[TORC2 signaling] GO:0061014[positive regulation of mRNA catabolic process] GO:0090316[positive regulation of intracellular protein transport]
Q6MZQ0 [Direct mapping] Proline-rich protein 5-like
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0005515[protein binding] GO:0006468[protein phosphorylation] GO:0009968[negative regulation of signal transduction] GO:0010762[regulation of fibroblast migration] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0031625[ubiquitin protein ligase binding] GO:0031932[TORC2 complex] GO:0034599[cellular response to oxidative stress] GO:0038203[TORC2 signaling] GO:0061014[positive regulation of mRNA catabolic process] GO:0090316[positive regulation of intracellular protein transport]
The Human Protein Atlas project is funded
