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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Hes related family bHLH transcription factor with YRPW motif 2
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q22.31
Chromosome location (bp)
125747664 - 125761269
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9UBP5 [Direct mapping] Hairy/enhancer-of-split related with YRPW motif protein 2
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Transporters Primary Active Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001570[vasculogenesis] GO:0003150[muscular septum morphogenesis] GO:0003151[outflow tract morphogenesis] GO:0003161[cardiac conduction system development] GO:0003171[atrioventricular valve development] GO:0003180[aortic valve morphogenesis] GO:0003184[pulmonary valve morphogenesis] GO:0003186[tricuspid valve morphogenesis] GO:0003195[tricuspid valve formation] GO:0003198[epithelial to mesenchymal transition involved in endocardial cushion formation] GO:0003199[endocardial cushion to mesenchymal transition involved in heart valve formation] GO:0003208[cardiac ventricle morphogenesis] GO:0003214[cardiac left ventricle morphogenesis] GO:0003215[cardiac right ventricle morphogenesis] GO:0003222[ventricular trabecula myocardium morphogenesis] GO:0003300[cardiac muscle hypertrophy] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007219[Notch signaling pathway] GO:0007389[pattern specification process] GO:0007507[heart development] GO:0009948[anterior/posterior axis specification] GO:0009952[anterior/posterior pattern specification] GO:0010460[positive regulation of heart rate] GO:0010468[regulation of gene expression] GO:0010621[negative regulation of transcription by transcription factor localization] GO:0010629[negative regulation of gene expression] GO:0010659[cardiac muscle cell apoptotic process] GO:0010667[negative regulation of cardiac muscle cell apoptotic process] GO:0014031[mesenchymal cell development] GO:0014898[cardiac muscle hypertrophy in response to stress] GO:0017053[transcription repressor complex] GO:0035910[ascending aorta morphogenesis] GO:0035912[dorsal aorta morphogenesis] GO:0036304[umbilical cord morphogenesis] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0043565[sequence-specific DNA binding] GO:0045165[cell fate commitment] GO:0045607[regulation of inner ear auditory receptor cell differentiation] GO:0045746[negative regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0050767[regulation of neurogenesis] GO:0051145[smooth muscle cell differentiation] GO:0055015[ventricular cardiac muscle cell development] GO:0060038[cardiac muscle cell proliferation] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060317[cardiac epithelial to mesenchymal transition] GO:0060347[heart trabecula formation] GO:0060411[cardiac septum morphogenesis] GO:0060412[ventricular septum morphogenesis] GO:0060413[atrial septum morphogenesis] GO:0060633[negative regulation of transcription initiation by RNA polymerase II] GO:0060716[labyrinthine layer blood vessel development] GO:0060837[blood vessel endothelial cell differentiation] GO:0060840[artery development] GO:0060842[arterial endothelial cell differentiation] GO:0060948[cardiac vascular smooth muscle cell development] GO:0060977[coronary vasculature morphogenesis] GO:0061156[pulmonary artery morphogenesis] GO:0061314[Notch signaling involved in heart development] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0065004[protein-DNA complex assembly] GO:0070168[negative regulation of biomineral tissue development] GO:0072359[circulatory system development] GO:0090102[cochlea development] GO:0097084[vascular associated smooth muscle cell development] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000678[negative regulation of transcription regulatory region DNA binding] GO:2000723[negative regulation of cardiac vascular smooth muscle cell differentiation] GO:2000820[negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation] GO:2001212[regulation of vasculogenesis]
The Human Protein Atlas project is funded
