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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q15
Chromosome location (bp)
68808177 - 68845544
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome 1. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation 2,3,4,5,6,7,8,9,10,11,12,13,14,15. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis 16. Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis 17....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000209[protein polyubiquitination] GO:0001568[blood vessel development] GO:0001974[blood vessel remodeling] GO:0002027[regulation of heart rate] GO:0002039[p53 binding] GO:0003170[heart valve development] GO:0003181[atrioventricular valve morphogenesis] GO:0003203[endocardial cushion morphogenesis] GO:0003281[ventricular septum development] GO:0003283[atrial septum development] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007089[traversing start control point of mitotic cell cycle] GO:0007507[heart development] GO:0008097[5S rRNA binding] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0010468[regulation of gene expression] GO:0016043[cellular component organization] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016874[ligase activity] GO:0016925[protein sumoylation] GO:0017053[transcription repressor complex] GO:0019789[SUMO transferase activity] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0030666[endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991[protein-containing complex] GO:0034504[protein localization to nucleus] GO:0036369[transcription factor catabolic process] GO:0042176[regulation of protein catabolic process] GO:0042802[identical protein binding] GO:0043021[ribonucleoprotein complex binding] GO:0043066[negative regulation of apoptotic process] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184[establishment of protein localization] GO:0045787[positive regulation of cell cycle] GO:0045892[negative regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0051149[positive regulation of muscle cell differentiation] GO:0051179[localization] GO:0051603[proteolysis involved in protein catabolic process] GO:0051726[regulation of cell cycle] GO:0051865[protein autoubiquitination] GO:0060411[cardiac septum morphogenesis] GO:0061630[ubiquitin protein ligase activity] GO:0061663[NEDD8 ligase activity] GO:0065003[protein-containing complex assembly] GO:0065008[regulation of biological quality] GO:0071456[cellular response to hypoxia] GO:0071480[cellular response to gamma radiation] GO:0072717[cellular response to actinomycin D] GO:0097718[disordered domain specific binding] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000[amyloid fibril formation]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000209[protein polyubiquitination] GO:0002039[p53 binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097[5S rRNA binding] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016043[cellular component organization] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016874[ligase activity] GO:0016925[protein sumoylation] GO:0017053[transcription repressor complex] GO:0019789[SUMO transferase activity] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0030666[endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991[protein-containing complex] GO:0034504[protein localization to nucleus] GO:0036369[transcription factor catabolic process] GO:0042176[regulation of protein catabolic process] GO:0042802[identical protein binding] GO:0043021[ribonucleoprotein complex binding] GO:0043066[negative regulation of apoptotic process] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184[establishment of protein localization] GO:0045892[negative regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0051179[localization] GO:0051603[proteolysis involved in protein catabolic process] GO:0051726[regulation of cell cycle] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061663[NEDD8 ligase activity] GO:0065003[protein-containing complex assembly] GO:0065008[regulation of biological quality] GO:0071456[cellular response to hypoxia] GO:0071480[cellular response to gamma radiation] GO:0072717[cellular response to actinomycin D] GO:0097718[disordered domain specific binding] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000[amyloid fibril formation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000209[protein polyubiquitination] GO:0002039[p53 binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097[5S rRNA binding] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016043[cellular component organization] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016874[ligase activity] GO:0016925[protein sumoylation] GO:0017053[transcription repressor complex] GO:0019789[SUMO transferase activity] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0030666[endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991[protein-containing complex] GO:0034504[protein localization to nucleus] GO:0036369[transcription factor catabolic process] GO:0042176[regulation of protein catabolic process] GO:0042802[identical protein binding] GO:0043021[ribonucleoprotein complex binding] GO:0043066[negative regulation of apoptotic process] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184[establishment of protein localization] GO:0045892[negative regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0051179[localization] GO:0051603[proteolysis involved in protein catabolic process] GO:0051726[regulation of cell cycle] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061663[NEDD8 ligase activity] GO:0065003[protein-containing complex assembly] GO:0065008[regulation of biological quality] GO:0071456[cellular response to hypoxia] GO:0071480[cellular response to gamma radiation] GO:0072717[cellular response to actinomycin D] GO:0097718[disordered domain specific binding] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000[amyloid fibril formation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000209[protein polyubiquitination] GO:0002039[p53 binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097[5S rRNA binding] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016043[cellular component organization] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016874[ligase activity] GO:0016925[protein sumoylation] GO:0017053[transcription repressor complex] GO:0019789[SUMO transferase activity] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0030666[endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991[protein-containing complex] GO:0034504[protein localization to nucleus] GO:0036369[transcription factor catabolic process] GO:0042176[regulation of protein catabolic process] GO:0042802[identical protein binding] GO:0043021[ribonucleoprotein complex binding] GO:0043066[negative regulation of apoptotic process] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184[establishment of protein localization] GO:0045892[negative regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0051179[localization] GO:0051603[proteolysis involved in protein catabolic process] GO:0051726[regulation of cell cycle] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061663[NEDD8 ligase activity] GO:0065003[protein-containing complex assembly] GO:0065008[regulation of biological quality] GO:0071456[cellular response to hypoxia] GO:0071480[cellular response to gamma radiation] GO:0072717[cellular response to actinomycin D] GO:0097718[disordered domain specific binding] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000[amyloid fibril formation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0005634[nucleus] GO:0016043[cellular component organization] GO:0016567[protein ubiquitination] GO:0043066[negative regulation of apoptotic process] GO:0051726[regulation of cell cycle]
Metabolic proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Q9H4C3 [Direct mapping] E3 ubiquitin-protein ligase Mdm2; p53 binding protein
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0005634[nucleus] GO:0016567[protein ubiquitination] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0046872[metal ion binding] GO:0051726[regulation of cell cycle] GO:0061630[ubiquitin protein ligase activity]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0005634[nucleus] GO:0016567[protein ubiquitination] GO:0043066[negative regulation of apoptotic process] GO:0051726[regulation of cell cycle]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000209[protein polyubiquitination] GO:0002039[p53 binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097[5S rRNA binding] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016043[cellular component organization] GO:0016567[protein ubiquitination] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016874[ligase activity] GO:0016925[protein sumoylation] GO:0017053[transcription repressor complex] GO:0019789[SUMO transferase activity] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0030666[endocytic vesicle membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031648[protein destabilization] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991[protein-containing complex] GO:0034504[protein localization to nucleus] GO:0036369[transcription factor catabolic process] GO:0042176[regulation of protein catabolic process] GO:0042802[identical protein binding] GO:0043021[ribonucleoprotein complex binding] GO:0043066[negative regulation of apoptotic process] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184[establishment of protein localization] GO:0045892[negative regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0046677[response to antibiotic] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0051179[localization] GO:0051603[proteolysis involved in protein catabolic process] GO:0051726[regulation of cell cycle] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061663[NEDD8 ligase activity] GO:0065003[protein-containing complex assembly] GO:0065008[regulation of biological quality] GO:0071456[cellular response to hypoxia] GO:0071480[cellular response to gamma radiation] GO:0072717[cellular response to actinomycin D] GO:0097718[disordered domain specific binding] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000[amyloid fibril formation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0005634[nucleus] GO:0016567[protein ubiquitination] GO:0043066[negative regulation of apoptotic process] GO:0051726[regulation of cell cycle]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
F5GZB0 [Direct mapping] E3 ubiquitin-protein ligase Mdm2; MDM2 protein
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
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