We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q35
Chromosome location (bp)
219279342 - 219286898
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family 1,2. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins 3,4. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes 5,6,7,8,9. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins 10....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P25686 [Direct mapping] DnaJ homolog subfamily B member 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671[ATPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005829[cytosol] GO:0006986[response to unfolded protein] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0030308[negative regulation of cell growth] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0030544[Hsp70 protein binding] GO:0031396[regulation of protein ubiquitination] GO:0031965[nuclear membrane] GO:0032091[negative regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032781[positive regulation of ATP-dependent activity] GO:0042026[protein refolding] GO:0043130[ubiquitin binding] GO:0051082[unfolded protein binding] GO:0051087[chaperone binding] GO:0061077[chaperone-mediated protein folding] GO:0070050[neuron cellular homeostasis] GO:0090084[negative regulation of inclusion body assembly] GO:0140036[ubiquitin-dependent protein binding] GO:1903644[regulation of chaperone-mediated protein folding]
P25686 [Direct mapping] DnaJ homolog subfamily B member 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502[proteasome complex] GO:0001671[ATPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005829[cytosol] GO:0006986[response to unfolded protein] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0016234[inclusion body] GO:0030308[negative regulation of cell growth] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0030544[Hsp70 protein binding] GO:0031396[regulation of protein ubiquitination] GO:0031398[positive regulation of protein ubiquitination] GO:0031593[polyubiquitin modification-dependent protein binding] GO:0031625[ubiquitin protein ligase binding] GO:0031965[nuclear membrane] GO:0032091[negative regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032781[positive regulation of ATP-dependent activity] GO:0032880[regulation of protein localization] GO:0042026[protein refolding] GO:0043130[ubiquitin binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051082[unfolded protein binding] GO:0051087[chaperone binding] GO:0061077[chaperone-mediated protein folding] GO:0070050[neuron cellular homeostasis] GO:0070628[proteasome binding] GO:0090084[negative regulation of inclusion body assembly] GO:0090086[negative regulation of protein deubiquitination] GO:0140036[ubiquitin-dependent protein binding] GO:1903644[regulation of chaperone-mediated protein folding]
C9JXB9 [Direct mapping] DnaJ homolog subfamily B member 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
E7ETU0 [Direct mapping] DnaJ homolog subfamily B member 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
C9JRD2 [Direct mapping] DnaJ homolog subfamily B member 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
C9JX00 [Direct mapping] DnaJ homolog subfamily B member 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
C9J1G2 [Direct mapping] DnaJ homolog subfamily B member 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
