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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes FDA approved drug targets G-protein coupled receptors Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q22.3
Chromosome location (bp)
77895481 - 77975529
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
G-protein coupled receptor, Receptor, Transducer
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P24530 [Direct mapping] Endothelin receptor type B
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A0A024R638 [Target identity:100%; Query identity:100%] Endothelin receptor type B
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G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Congenital disorders of metabolism Other congenital disorders of metabolism Congenital malformations Congenital malformations of the digestive system Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004930[G protein-coupled receptor activity] GO:0004962[endothelin receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007399[nervous system development] GO:0008015[blood circulation] GO:0008217[regulation of blood pressure] GO:0014043[negative regulation of neuron maturation] GO:0014826[vein smooth muscle contraction] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0017046[peptide hormone binding] GO:0019722[calcium-mediated signaling] GO:0035556[intracellular signal transduction] GO:0035645[enteric smooth muscle cell differentiation] GO:0042310[vasoconstriction] GO:0048066[developmental pigmentation] GO:0048246[macrophage chemotaxis] GO:0048484[enteric nervous system development] GO:0051248[negative regulation of protein metabolic process] GO:0065008[regulation of biological quality] GO:0086100[endothelin receptor signaling pathway]
P24530 [Direct mapping] Endothelin receptor type B
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G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Congenital disorders of metabolism Other congenital disorders of metabolism Congenital malformations Congenital malformations of the digestive system Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004930[G protein-coupled receptor activity] GO:0004962[endothelin receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007399[nervous system development] GO:0008015[blood circulation] GO:0008217[regulation of blood pressure] GO:0014043[negative regulation of neuron maturation] GO:0014826[vein smooth muscle contraction] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0017046[peptide hormone binding] GO:0019722[calcium-mediated signaling] GO:0035556[intracellular signal transduction] GO:0035645[enteric smooth muscle cell differentiation] GO:0042310[vasoconstriction] GO:0048066[developmental pigmentation] GO:0048246[macrophage chemotaxis] GO:0048484[enteric nervous system development] GO:0051248[negative regulation of protein metabolic process] GO:0065008[regulation of biological quality] GO:0086100[endothelin receptor signaling pathway]
P24530 [Direct mapping] Endothelin receptor type B
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A0A024R645 [Target identity:100%; Query identity:100%] Endothelin receptor type B
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G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Congenital disorders of metabolism Other congenital disorders of metabolism Congenital malformations Congenital malformations of the digestive system Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004930[G protein-coupled receptor activity] GO:0004962[endothelin receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007399[nervous system development] GO:0008015[blood circulation] GO:0008217[regulation of blood pressure] GO:0014043[negative regulation of neuron maturation] GO:0014826[vein smooth muscle contraction] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0017046[peptide hormone binding] GO:0019722[calcium-mediated signaling] GO:0035556[intracellular signal transduction] GO:0035645[enteric smooth muscle cell differentiation] GO:0042310[vasoconstriction] GO:0048066[developmental pigmentation] GO:0048246[macrophage chemotaxis] GO:0048484[enteric nervous system development] GO:0051248[negative regulation of protein metabolic process] GO:0065008[regulation of biological quality] GO:0086100[endothelin receptor signaling pathway]
P24530 [Direct mapping] Endothelin receptor type B
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G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Congenital disorders of metabolism Other congenital disorders of metabolism Congenital malformations Congenital malformations of the digestive system Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004930[G protein-coupled receptor activity] GO:0004962[endothelin receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007399[nervous system development] GO:0008015[blood circulation] GO:0008217[regulation of blood pressure] GO:0014043[negative regulation of neuron maturation] GO:0014826[vein smooth muscle contraction] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0017046[peptide hormone binding] GO:0019722[calcium-mediated signaling] GO:0035556[intracellular signal transduction] GO:0035645[enteric smooth muscle cell differentiation] GO:0042310[vasoconstriction] GO:0048066[developmental pigmentation] GO:0048246[macrophage chemotaxis] GO:0048484[enteric nervous system development] GO:0051248[negative regulation of protein metabolic process] GO:0065008[regulation of biological quality] GO:0086100[endothelin receptor signaling pathway]
P24530 [Direct mapping] Endothelin receptor type B
Show all
G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Congenital disorders of metabolism Other congenital disorders of metabolism Congenital malformations Congenital malformations of the digestive system Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001755[neural crest cell migration] GO:0001934[positive regulation of protein phosphorylation] GO:0002001[renin secretion into blood stream] GO:0002027[regulation of heart rate] GO:0004930[G protein-coupled receptor activity] GO:0004962[endothelin receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0006885[regulation of pH] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007399[nervous system development] GO:0007422[peripheral nervous system development] GO:0007497[posterior midgut development] GO:0007568[aging] GO:0008015[blood circulation] GO:0008217[regulation of blood pressure] GO:0008284[positive regulation of cell population proliferation] GO:0010033[response to organic substance] GO:0010467[gene expression] GO:0014043[negative regulation of neuron maturation] GO:0014070[response to organic cyclic compound] GO:0014826[vein smooth muscle contraction] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0017046[peptide hormone binding] GO:0019233[sensory perception of pain] GO:0019722[calcium-mediated signaling] GO:0019934[cGMP-mediated signaling] GO:0030202[heparin metabolic process] GO:0030318[melanocyte differentiation] GO:0031620[regulation of fever generation] GO:0031702[type 1 angiotensin receptor binding] GO:0031965[nuclear membrane] GO:0032341[aldosterone metabolic process] GO:0032496[response to lipopolysaccharide] GO:0035556[intracellular signal transduction] GO:0035645[enteric smooth muscle cell differentiation] GO:0035810[positive regulation of urine volume] GO:0035812[renal sodium excretion] GO:0035815[positive regulation of renal sodium excretion] GO:0042045[epithelial fluid transport] GO:0042310[vasoconstriction] GO:0042311[vasodilation] GO:0043066[negative regulation of apoptotic process] GO:0043473[pigmentation] GO:0045121[membrane raft] GO:0048066[developmental pigmentation] GO:0048246[macrophage chemotaxis] GO:0048265[response to pain] GO:0048484[enteric nervous system development] GO:0050678[regulation of epithelial cell proliferation] GO:0051248[negative regulation of protein metabolic process] GO:0051930[regulation of sensory perception of pain] GO:0055078[sodium ion homeostasis] GO:0060070[canonical Wnt signaling pathway] GO:0060406[positive regulation of penile erection] GO:0060465[pharynx development] GO:0061028[establishment of endothelial barrier] GO:0065008[regulation of biological quality] GO:0070294[renal sodium ion absorption] GO:0070588[calcium ion transmembrane transport] GO:0071222[cellular response to lipopolysaccharide] GO:0071806[protein transmembrane transport] GO:0072112[podocyte differentiation] GO:0086100[endothelin receptor signaling pathway] GO:0097018[renal albumin absorption] GO:0097402[neuroblast migration] GO:1904383[response to sodium phosphate] GO:1990839[response to endothelin]
P24530 [Direct mapping] Endothelin receptor type B
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G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Head and neck cancers Congenital disorders of metabolism Other congenital disorders of metabolism Congenital malformations Congenital malformations of the digestive system Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004930[G protein-coupled receptor activity] GO:0004962[endothelin receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007399[nervous system development] GO:0008015[blood circulation] GO:0008217[regulation of blood pressure] GO:0014043[negative regulation of neuron maturation] GO:0014826[vein smooth muscle contraction] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0017046[peptide hormone binding] GO:0019722[calcium-mediated signaling] GO:0035556[intracellular signal transduction] GO:0035645[enteric smooth muscle cell differentiation] GO:0042310[vasoconstriction] GO:0048066[developmental pigmentation] GO:0048246[macrophage chemotaxis] GO:0048484[enteric nervous system development] GO:0051248[negative regulation of protein metabolic process] GO:0065008[regulation of biological quality] GO:0086100[endothelin receptor signaling pathway]
The Human Protein Atlas project is funded
