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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Monocyte to macrophage differentiation associated 2
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p22.1
Chromosome location (bp)
4905989 - 4959213
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
GO:0000139[Golgi membrane] GO:0004672[protein kinase activity] GO:0005794[Golgi apparatus] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0032880[regulation of protein localization] GO:0045666[positive regulation of neuron differentiation] GO:0045860[positive regulation of protein kinase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048471[perinuclear region of cytoplasm]
GO:0000139[Golgi membrane] GO:0004672[protein kinase activity] GO:0005794[Golgi apparatus] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0032880[regulation of protein localization] GO:0045666[positive regulation of neuron differentiation] GO:0045860[positive regulation of protein kinase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048471[perinuclear region of cytoplasm]
GO:0000139[Golgi membrane] GO:0004672[protein kinase activity] GO:0005794[Golgi apparatus] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0032880[regulation of protein localization] GO:0045666[positive regulation of neuron differentiation] GO:0045860[positive regulation of protein kinase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048471[perinuclear region of cytoplasm]
The Human Protein Atlas project is funded
