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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q12
Chromosome location (bp)
24305187 - 24311430
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion 1. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage 2. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (By similarity). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (By similarity). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (By similarity). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (By similarity). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (By similarity). May also activate apoptosis 3....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables identical protein binding activity. Involved in activation of cysteine-type endopeptidase activity; positive regulation of cell death; and positive regulation of release of cytochrome c from mitochondria. Acts upstream of or within apoptotic process. Located in cytosol and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9UHD4 [Direct mapping] Cell death activator CIDE-B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0005515[protein binding] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010942[positive regulation of cell death] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0048471[perinuclear region of cytoplasm] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097194[execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity]
Q9UHD4 [Direct mapping] Cell death activator CIDE-B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005515[protein binding] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010942[positive regulation of cell death] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0048471[perinuclear region of cytoplasm] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097194[execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity]
Q9UHD4 [Direct mapping] Cell death activator CIDE-B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005515[protein binding] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010942[positive regulation of cell death] GO:0031667[response to nutrient levels] GO:0038183[bile acid signaling pathway] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0048471[perinuclear region of cytoplasm] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097194[execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity]
The Human Protein Atlas project is funded
