GENERAL INFORMATIONi
Gene namei BIN1
Synonyms AMPH2, AMPHL, SH3P9
Gene descriptioni Bridging integrator 1
Protein classi Disease related genes
Human disease related genes
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 2
Cytoband q14.3
Chromosome location (bp) 127048027 - 127107288
Number of transcriptsi 11
Ensembl ENSG00000136717 (version 109)
Entrez gene 274
HGNC HGNC:1052
UniProt O00499 (UniProt - Evidence at protein level)
neXtProt NX_O00499
GeneCards BIN1
Antibodypedia BIN1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling 1. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production 2. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation 3. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro 4. show less
Molecular function (UniProt)i Developmental protein
Biological process (UniProt)i Differentiation, Endocytosis, Host-virus interaction
Gene summary (Entrez)i This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
BIN1-201
ENSP00000259238
ENST00000259238
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAJ2
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_h
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 497 aa
54.9 kDa 		No 0
BIN1-202
ENSP00000316779
ENST00000316724
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAF1
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_k
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043196 [varicosity]
GO:0043229 [intracellular organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0043679 [axon terminus]
GO:0044300 [cerebellar mossy fiber]
GO:0044877 [protein-containing complex binding]
GO:0045202 [synapse]
GO:0045664 [regulation of neuron differentiation]
GO:0045807 [positive regulation of endocytosis]
GO:0048156 [tau protein binding]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051020 [GTPase binding]
GO:0051087 [chaperone binding]
GO:0051647 [nucleus localization]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:0098850 [extrinsic component of synaptic vesicle membrane]
GO:0098978 [glutamatergic synapse]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 593 aa
64.7 kDa 		No 0
BIN1-203
ENSP00000315411
ENST00000346226
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAF0
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_c
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 518 aa
56.5 kDa 		No 0
BIN1-204
ENSP00000259237
ENST00000348750
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAI6
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_g
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 409 aa
45.6 kDa 		No 0
BIN1-205
ENSP00000315388
ENST00000351659
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAJ3
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_i
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 506 aa
55.2 kDa 		No 0
BIN1-206
ENSP00000315284
ENST00000352848
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAE9
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_d
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 454 aa
50.2 kDa 		No 0
BIN1-207
ENSP00000350654
ENST00000357970
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAF6
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_e
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 550 aa
59.9 kDa 		No 0
BIN1-208
ENSP00000365281
ENST00000376113
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAG9
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_j
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 424 aa
47.5 kDa 		No 0
BIN1-209
ENSP00000376760
ENST00000393040
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAI5
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 482 aa
53 kDa 		No 0
BIN1-210
ENSP00000376761
ENST00000393041
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAI4
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 475 aa
51.7 kDa 		No 0
BIN1-211
ENSP00000386797
ENST00000409400
O00499
[Direct mapping] Myc box-dependent-interacting protein 1
Show all
A0A024RAG8
[Target identity:100%; Query identity:100%] Bridging integrator 1, isoform CRA_f
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Human disease related genes
   Musculoskeletal diseases
   Muscular diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006997 [nucleus organization]
GO:0007010 [cytoskeleton organization]
GO:0008021 [synaptic vesicle]
GO:0008333 [endosome to lysosome transport]
GO:0010564 [regulation of cell cycle process]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0019828 [aspartic-type endopeptidase inhibitor activity]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031674 [I band]
GO:0031982 [vesicle]
GO:0033268 [node of Ranvier]
GO:0033292 [T-tubule organization]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043229 [intracellular organelle]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0051015 [actin filament binding]
GO:0051087 [chaperone binding]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090571 [RNA polymerase II transcription repressor complex]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902430 [negative regulation of amyloid-beta formation]
GO:1902960 [negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1903946 [negative regulation of ventricular cardiac muscle cell action potential]
GO:1904878 [negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 439 aa
48.3 kDa 		No 0

Contact

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The Human Protein Atlas

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